Effects of Dopamine on the Immature Neurons of the Adult Rat Piriform Cortex
View/ Open
Impact
Scholar |
Other documents of the author: Coviello, Simona; Montes Cebrián, Yaiza; Castillo-Gómez, Esther; Nacher, Juan
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
Effects of Dopamine on the Immature Neurons of the Adult Rat Piriform CortexDate
2020-10-06Publisher
Frontiers MediaISSN
1662-453XBibliographic citation
Coviello S, Gramuntell Y, Castillo-Gomez E and Nacher J (2020) Effects of Dopamine on the Immature Neurons of the Adult Rat Piriform Cortex. Front. Neurosci. 14:574234. doi: 10.3389/fnins.2020.574234Type
info:eu-repo/semantics/articlePublisher version
https://www.frontiersin.org/articles/10.3389/fnins.2020.574234/fullVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
The layer II of the adult piriform cortex (PCX) contains a numerous population of immature neurons. Interestingly, in both mice and rats, most, if not all, these cells have an embryonic origin. Moreover, recent studies ... [+]
The layer II of the adult piriform cortex (PCX) contains a numerous population of immature neurons. Interestingly, in both mice and rats, most, if not all, these cells have an embryonic origin. Moreover, recent studies from our laboratory have shown that they progressively mature into typical excitatory neurons of the PCX layer II. Therefore, the adult PCX is considered a “non-canonical” neurogenic niche. These immature neurons express the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), a molecule critical for different neurodevelopmental processes. Dopamine (DA) is a relevant neurotransmitter in the adult CNS, which also plays important roles in neural development and adult plasticity, including the regulation of PSA-NCAM expression. In order to evaluate the hypothetical effects of pharmacological modulation of dopaminergic neurotransmission on the differentiation of immature neurons of the adult PCX, we studied dopamine D2 receptor (D2r) expression in this region and the relationship between dopaminergic fibers and immature neurons (defined by PSA-NCAM expression). In addition, we analyzed the density of immature neurons after chronic treatments with an antagonist and an agonist of D2r: haloperidol and PPHT, respectively. Many dopaminergic fibers were observed in close apposition to PSA-NCAM-expressing neurons, which also coexpressed D2r. Chronic treatment with haloperidol significantly increased the number of PSA-NCAM immunoreactive cells, while PPHT treatment decreased it. These results indicate a prominent role of dopamine, through D2r and PSA-NCAM, on the regulation of the final steps of development of immature neurons in the adult PCX. [-]
Is part of
Frontiers in Neuroscience (2020), 14, 574234Investigation project
Spanish Ministry of Science and Innovation (RTI2018-098269-B-I00 and RTI2018-095698- B-I00) and the Generalitat Valenciana (PROMETEU/2020/024). SC has a predoctoral fellowship from the Generalitat Valenciana (GRISOLIAP/2017/087).Rights
info:eu-repo/semantics/openAccess
This item appears in the folowing collection(s)
- MED_Articles [667]
The following license files are associated with this item: