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dc.contributor.authorFaivre, Fanny
dc.contributor.authorSánchez-Catalán, María José
dc.contributor.authorDovero, Sandra
dc.contributor.authorBido, Simone
dc.contributor.authorJoshi, Anil
dc.contributor.authorBezard, Erwan
dc.contributor.authorBarrot, Michel
dc.date.accessioned2020-10-28T11:07:33Z
dc.date.available2020-10-28T11:07:33Z
dc.date.issued2020
dc.identifier.citationFAIVRE, Fanny, et al. Ablation of the tail of the ventral tegmental area compensates symptoms in an experimental model of Parkinson's disease. Neurobiology of Disease, 2020, vol. 139, p. 104818.ca_CA
dc.identifier.issn0969-9961
dc.identifier.urihttp://hdl.handle.net/10234/190128
dc.description.abstractParkinson's disease is a neurodegenerative disorder partly caused by the loss of the dopamine neurons of the nigrostriatal pathway. It is accompanied by motor as well as non-motor symptoms, including pain and depression. The tail of the ventral tegmental area (tVTA) or rostromedial tegmental nucleus (RMTg) is a GABAergic mesopontine structure that acts as a major inhibitory brake for the substantia nigra pars compacta (SNc) dopamine cells, thus controlling their neuronal activity and related motor functions. The present study tested the influence of suppressing this tVTA brake on motor and non-motor symptoms in a rat model of Parkinson's disease. Using behavioral approaches, we showed that male Sprague-Dawley rats with bilateral and partial 6-hydroxydopamine SNc lesion displayed motor impairments in the rotarod test, impairments that were no more present following a co-lesion of the tVTA. Using a larger set of behavioral tests, we then showed that such SNc lesion also led to non-motor symptoms, including lower body weight, lower mechanical nociceptive thresholds in the forceps test and lower thermal nociceptive thresholds in the incremented hot-plate test, and a decreased sucrose preference in a 2-bottle choice paradigm. The excitotoxic co-lesion of the tVTA led to compensation of body weight, mechanical nociceptive thresholds and anhedonia-like behavior. These findings illustrate the major influence that the tVTA exerts on the dopamine system, modulating the motor and non-motor symptoms related to a partial loss of dopamine cells.ca_CA
dc.format.extent10 p.ca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfNeurobiology of Disease, 2020, vol. 139.ca_CA
dc.rights0969-9961/ © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).Tca_CA
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRostromedial tegmental nucleusca_CA
dc.subjectSubstantia nigraca_CA
dc.subjectParkinson's diseaseca_CA
dc.subjectPainca_CA
dc.subjectDepressionca_CA
dc.titleAblation of the tail of the ventral tegmental area compensates symptoms in an experimental model of Parkinson's diseaseca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1016/j.nbd.2020.104818
dc.relation.projectIDUPR3212, UMR5293, ANR-15-CE37-0005-02, Euridol ANR-17-EURE-0022, FDT20170437322, 24220ca_CA
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttps://www.sciencedirect.com/science/article/pii/S0969996120300930ca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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0969-9961/ © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).T
Excepto si se señala otra cosa, la licencia del ítem se describe como: 0969-9961/ © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).T