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Bogota River anthropogenic contamination alters microbial communities and promotes spread of antibiotic resistance genes
dc.contributor.author | Posada-Perlaza, Carlos Eduardo | |
dc.contributor.author | Ramírez-Rojas, Adán | |
dc.contributor.author | Porras, Paola | |
dc.contributor.author | Adu-Oppong, Boahemaa | |
dc.contributor.author | Botero-Coy, Ana Maria | |
dc.contributor.author | Hernandez, Felix | |
dc.contributor.author | Anzola, Juan | |
dc.contributor.author | Díaz, Lorena | |
dc.contributor.author | Dantas, Gautam | |
dc.contributor.author | Reyes, Alejandro | |
dc.contributor.author | Zambrano, Maria Mercedes | |
dc.date.accessioned | 2020-10-15T14:25:01Z | |
dc.date.available | 2020-10-15T14:25:01Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | POSADA-PERLAZA, Carlos Eduardo, et al. Bogotá River anthropogenic contamination alters microbial communities and promotes spread of antibiotic resistance genes. Scientific reports, 2019, vol. 9, núm. 1, p. 1-13 | ca_CA |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10234/189974 | |
dc.description.abstract | The increase in antibiotic resistant bacteria has raised global concern regarding the future effectiveness of antibiotics. Human activities that influence microbial communities and environmental resistomes can generate additional risks to human health. In this work, we characterized aquatic microbial communities and their resistomes in samples collected at three sites along the Bogotá River and from wastewaters at three city hospitals, and investigated community profiles and antibiotic resistance genes (ARGs) as a function of anthropogenic contamination. The presence of antibiotics and other commonly used drugs increased in locations highly impacted by human activities, while the diverse microbial communities varied among sites and sampling times, separating upstream river samples from more contaminated hospital and river samples. Clinically relevant antibiotic resistant pathogens and ARGs were more abundant in contaminated water samples. Tracking of resistant determinants to upstream river waters and city sources suggested that human activities foster the spread of ARGs, some of which were co-localized with mobile genetic elements in assembled metagenomic contigs. Human contamination of this water ecosystem changed both community structure and environmental resistomes that can pose a risk to human health. | ca_CA |
dc.format.extent | 13 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Nature Research | ca_CA |
dc.relation.isPartOf | Scientific reports, 2019, vol. 9, núm. 1, p. 1-13 | ca_CA |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2019 | ca_CA |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.title | Bogota River anthropogenic contamination alters microbial communities and promotes spread of antibiotic resistance genes | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1038/s41598-019-48200-6 | |
dc.relation.projectID | Funding was provided by Colciencias (project No. 657065741359) | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.nature.com/articles/s41598-019-48200-6 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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© The Author(s) 2019