Inflammation and Cognition in Children and Adolescents: A Call for Action
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Título
Inflammation and Cognition in Children and Adolescents: A Call for ActionFecha de publicación
2020-09-09Cita bibliográfica
ADELANTADO-RENAU, Mireia; BELTRAN-VALLS, Maria Reyes; MOLINER-URDIALES, Diego. Inflammation and cognition in children and adolescents: a call for action. Frontiers in Pediatrics, 2020, vol. 8, p. 583.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.frontiersin.org/articles/10.3389/fped.2020.00583/fullVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Inflammation is a natural response to injury or infection, which promotes tissue survival,
remodeling, and repair, as well as adaptation to stress and restoration of the homeostatic state (1).
In the acute phase of ... [+]
Inflammation is a natural response to injury or infection, which promotes tissue survival,
remodeling, and repair, as well as adaptation to stress and restoration of the homeostatic state (1).
In the acute phase of an inflammatory response, which could persist for a few days, inflammatory
factors such as cytokines/chemokines, immune-related effectors, acute phase proteins, and reactive
oxygen and nitrogen species are released, thereby triggering coordinated biological events (1).
However, a prolonged inflammatory response, also known as chronic low-grade inflammation
(1), may contribute to the pathogenesis of several cardiovascular and metabolic diseases (e.g.,
atherosclerosis, diabetes, and cancer) (2, 3) as well as to the development of neuropsychiatric
disorders and cognitive dysfunctions (4).
Cognition involves a set of mental processes that shape perception, memory, intellect, and
action, including executive functions (e.g., cognitive inhibition, cognitive flexibility, and working
memory), and other cognitive domains (e.g., verbal fluency and comprehension) (5). Although it
has been suggested that the immune system might modulate brain functioning, how inflammatory
factors could influence cognition is poorly understood. Here, we provide context and three open
questions that need to be answered to move the field forward. [-]
Publicado en
Frontiers in Pediatrics, 2020, v. 8Proyecto de investigación
The DADOS Study was funded by the Spanish Ministry of Economy and Competitiveness, MINECO (DEP2013-45515-R), and the Jaume I University of Castellon, UJI (P1·1A2015-05 and UJI-A2019-12). This work was partly supported by a Sunny Sport research grant from the Schweppes Suntory Spain Company.Derechos de acceso
info:eu-repo/semantics/openAccess
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