Rehospitalization burden and morbidity risk in patients with heart failure with mid-range ejection fraction
![Thumbnail](/xmlui/bitstream/handle/10234/189939/Santas2020.pdf.jpg?sequence=5&isAllowed=y)
Ver/ Abrir
Impacto
![Google Scholar](/xmlui/themes/Mirage2/images/uji/logo_google.png)
![Microsoft Academico](/xmlui/themes/Mirage2/images/uji/logo_microsoft.png)
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
Rehospitalization burden and morbidity risk in patients with heart failure with mid-range ejection fractionAutoría
Fecha de publicación
2020-03-25Editor
WileyCita bibliográfica
SANTAS, Enrique, et al. Rehospitalization burden and morbidity risk in patients with heart failure with mid‐range ejection fraction. ESC heart failure, 2020.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://onlinelibrary.wiley.com/doi/10.1002/ehf2.12683Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Aims Heart failure with mid-range ejection fraction (HFmrEF) has been proposed as a distinct HF phenotype, but whether
patients on this category fare worse, similarly, or better than those with HF with reduced EF ... [+]
Aims Heart failure with mid-range ejection fraction (HFmrEF) has been proposed as a distinct HF phenotype, but whether
patients on this category fare worse, similarly, or better than those with HF with reduced EF (HFrEF) or preserved EF (HFpEF)
in terms of rehospitalization risks over time remains unclear.
Methods and results We prospectively included 2961 consecutive patients admitted for acute HF (AHF) in our institution. Of
them, 158 patients died during the index admission, leaving the sample size to be 2803 patients. Patients were categorized
according to their EF: HFrEF if EF ≤ 40% (n = 908, 32.4%); HFmrEF if EF = 41–49% (n = 449, 16.0%); and HFpEF if EF ≥ 50%
(n = 1446, 51.6%). Covariate-adjusted incidence rate ratios (IRRs) were used to evaluate the association between EF status
and recurrent all-cause and HF-related admissions. At a median follow-up of 2.6 years (inter-quartile range: 1.0–5.3), 1663
(59.3%) patients died, and 6035 all-cause readmissions were registered in 2026 patients (72.3%), 2163 of them HF related.
Rates of all-cause readmission per 100 patients-years of follow-up were 150.1, 176.9, and 163.6 in HFrEF, HFmrEF, and HFpEF,
respectively (P = 0.097). After multivariable adjustment, when compared with that of patients with HFrEF and HFpEF, HFmrEF
status was not significantly associated with a different risk of all-cause readmissions (IRR = 0.99; 95% confidence interval [CI],
0.77–1.27; P = 0.926; and IRR = 0.93; 95% CI, 0.74–1.18; P = 0.621, respectively) or HF-related readmissions (IRR = 1.06; 95% CI,
0.77–1.46; P = 0.725; and IRR = 1.11; 95% CI, 0.82–1.50; P = 0.511, respectively).
Conclusions Following an admission for AHF, patients with HFmrEF had a similar rehospitalization burden and a similar risk of
recurrent all-cause and HF-related admissions than had patients with HFrEF or HFpEF. Regarding morbidity risk, HFmrEF seems
not to be a distinct HF phenotype. [-]
Publicado en
ESC Heart Failure, 2020, v. 7Derechos de acceso
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- MED_Articles [655]
El ítem tiene asociados los siguientes ficheros de licencia: