Analysis of LDL and HDL size and number by nuclear magnetic resonance in a healthy working population: the LipoLab Study
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https://doi.org/10.1111/ijcp.13610 |
Metadades
Títol
Analysis of LDL and HDL size and number by nuclear magnetic resonance in a healthy working population: the LipoLab StudyAutoria
Data de publicació
2020Editor
WileyISSN
1368-5031; 1742-1241Cita bibliogràfica
Vicente Pallarés‐Carratalá, et al., Analysis of LDL and HDL size and number by nuclear magnetic resonance in a healthy working population: the LipoLab Study. International Journal of Clinical Practice, 2020Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://onlinelibrary.wiley.com/doi/abs/10.1111/ijcp.13610Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Background and aim
Atherosclerosis is the underlying process in cardiovascular disease (CVD), the first cause of death in developed countries. We aimed to identify people with no known CVD and normal values of LDL‐C ... [+]
Background and aim
Atherosclerosis is the underlying process in cardiovascular disease (CVD), the first cause of death in developed countries. We aimed to identify people with no known CVD and normal values of LDL‐C and HDL‐C, but with alterations in the number and size of lipoprotein particles (as measured by nuclear magnetic resonance [NMR]) and to analyze their sociodemographic, clinical, and biochemical characteristics.
Methods
Cross‐sectional study in occupational risks prevention center in Castellón (Spain) in 2017 and 2018, in consecutively recruited adults (18‐65 years) with no known CVD. Sociodemographic, clinical and biochemical variables were collected. Lipid profiles were analyzed (Liposcale test), along with the concentration, size and number of the main types of lipoprotein particles, determined by 2D diffusion‐ordered NMR spectroscopy. Using contingency tables, we analyzed the characteristics of people with normal LDL and HDL cholesterol but abnormal levels of LDL and HDL particles. The magnitude of association between explanatory variables and abnormal levels of each kind of lipoprotein was assessed with multivariable logistic regression models.
Results
Of the 400 total participants (31.3% women; age 46.4±4.3 years), 169 had normal LDL and HDL cholesterol. Abnormal lipoprotein particle values depended on the subtype: prevalence of abnormal LDL levels ranged from 8.3% to 36.7%; and of HDL, from 28.4% to 42.6%. High systolic blood pressure and total cholesterol were significantly associated with abnormal LDL levels. Male sex and high systolic blood pressure were associated with abnormalities in HDL.
Conclusions
An extended lipids profile, obtained by NMR, enables the identification of people with normal HDL‐C and LDL‐C levels who present abnormal levels of LDL‐P and/or HDL‐P. Higher total cholesterol, systolic blood pressure, BMI, and male sex were significantly associated with these abnormal values. [-]
Publicat a
International Journal of Clinical Practice, 2020Drets d'accés
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/ijcp.13610
This article is protected by copyright. All rights reserved
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