A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction
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Título
A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and AddictionAutoría
Fecha de publicación
2020-04-07Editor
Frontiers MediaCita bibliográfica
GUIRADO, Ramón; PÉREZ-RANDO, Marta; FERRAGUD, Antonio; GUTIÉRREZ-CASTELLANOS, Nicolás; UMEMORI, Juzoh; CARCELLER, Héctor; NACHER, Juan; CASTILLO-GOMEZ, Esther (2020). A Critical Period for Prefrontal Network Configurations Underlying Psychiatric Disorders and Addiction. Frontiers in Behavioral Neuroscience, v., v. 14, art. 51Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.frontiersin.org/articles/10.3389/fnbeh.2020.00051/fullVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The medial prefrontal cortex (mPFC) has been classically defined as the brain region
responsible for higher cognitive functions, including the decision-making process. Ample
information has been gathered during the ... [+]
The medial prefrontal cortex (mPFC) has been classically defined as the brain region
responsible for higher cognitive functions, including the decision-making process. Ample
information has been gathered during the last 40 years in an attempt to understand
how it works. We now know extensively about the connectivity of this region and
its relationship with neuromodulatory ascending projection areas, such as the dorsal
raphe nucleus (DRN) or the ventral tegmental area (VTA). Both areas are well-known
regulators of the reward-based decision-making process and hence likely to be involved
in processes like evidence integration, impulsivity or addiction biology, but also in helping
us to predict the valence of our future actions: i.e., what is “good” and what is “bad.”
Here we propose a hypothesis of a critical period, during which the inputs of the mPFC
compete for target innervation, establishing specific prefrontal network configurations
in the adult brain. We discuss how these different prefrontal configurations are linked
to brain diseases such as addiction or neuropsychiatric disorders, and especially how
drug abuse and other events during early life stages might lead to the formation of
more vulnerable prefrontal network configurations. Finally, we show different promising
pharmacological approaches that, when combined with the appropriate stimuli, will be
able to re-establish these functional prefrontocortical configurations during adulthood. [-]
Publicado en
Frontiers in Behavioral Neuroscience (2020), v. 14Proyecto de investigación
1) ERC grant No. 322742—iPLASTICITY, by the Spanish Ministry of XXX to EC-G (RTI2018-095698-B-I00) and to JN (RTI2018-098269-B-I00) and 2) “Proyectos de I+D+i desarrollados por grupos de investigación emergentes” (GV/2019/088) to EC-G and RG. “Atracció de Talent” grant from the University of Valencia (#664878) and 3) “Juan de la Cierva” (IJCI-2016-27758) to RG.Derechos de acceso
info:eu-repo/semantics/openAccess
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