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Enantiomeric profiling of quinolones and quinolones resistance gene qnrS in European wastewaters
dc.contributor.author | Castrignano', Erika | |
dc.contributor.author | Yang, Zhugen | |
dc.contributor.author | Feil, Edward | |
dc.contributor.author | Bade, Richard | |
dc.contributor.author | Castiglioni, Sara | |
dc.contributor.author | Causanilles, Ana | |
dc.contributor.author | GRACIA LOR, EMMA | |
dc.contributor.author | Hernandez, Felix | |
dc.contributor.author | Plosz, Benedek | |
dc.contributor.author | Ramin, Pedram | |
dc.contributor.author | Rousis, Nikolaos I | |
dc.contributor.author | Ryu, Yeonsuk | |
dc.contributor.author | Thomas, Kevin | |
dc.contributor.author | de Voogt, Pim | |
dc.contributor.author | Zuccato, Ettore | |
dc.contributor.author | Kasprzyk-Hordern, Barbara | |
dc.date.accessioned | 2020-05-26T18:58:42Z | |
dc.date.available | 2020-05-26T18:58:42Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | CASTRIGNANÒ, Erika, et al. Enantiomeric profiling of quinolones and quinolones resistance gene qnrS in European wastewaters. Water Research, 2020, p. 115653 | ca_CA |
dc.identifier.issn | 0043-1354 | |
dc.identifier.issn | 1879-2448 | |
dc.identifier.uri | http://hdl.handle.net/10234/188297 | |
dc.description.abstract | Wastewater-based epidemiology (WBE) was applied for the first time in seven cities across Europe with the aim of estimating quinolones consumption via the analysis of human urinary metabolites in wastewater. This report is also the first pan-European study focussed on the enantiomeric profiling of chiral quinolones in wastewater. By considering loads of (fluoro)quinolones in wastewater within the context of human stereoselective metabolism, we identified cities in Southern Europe characterised by both high usage and direct disposal of unused ofloxacin. In Northern European cities, S-(-)-ofloxacin loads were predominant with respect to R-(+)-ofloxacin. Much more potent, enantiomerically pure S-(-)-ofloxacin was detected in wastewaters from Southern European cities, reflecting consumption of the enantiomerically pure antibiotic. Nalidixic acid, norfloxacin and lomefloxacin were detected in wastewater even though they were not prescribed according to official prescription data. S,S-(-)-moxifloxacin and S,S-(-)-moxifloxacin-N-sulphate were detected in wastewater due to metabolism of moxifloxacin. For the first time, average population-normalised ulifloxacin loads of 22.3 and 1.5 mg day−1 1000 people−1 were reported for Milan and Castellón as a result of prulifloxacin metabolism. Enrichment of flumequine with first-eluting enantiomer in all the samples indicated animal metabolism rather than its direct disposal. Fluoroquinolone loads were compared with qnrS gene encoding quinolone resistance to correlate usage of fluoroquinolone and prevalence of resistance. The highest daily loads of the qnrS gene in Milan corresponded with the highest total quinolone load in Milan proving the hypothesis that higher usage of quinolones is linked with higher prevalence of quinolone resistance genes. Utrecht, with the lowest quinolones usage (low daily loads) had also one of the lowest daily loads of the qnrS gene. However, a similar trend was not observed in Oslo nor Bristol where higher qnrS gene loads were observed despite low quinolone usage. | ca_CA |
dc.format.extent | 14 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Water Research, 2020, p. 115653 | ca_CA |
dc.rights | © 2020 Elsevier Ltd. All rights reserved. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | chiral antibiotics | ca_CA |
dc.subject | enantioselective analysis | ca_CA |
dc.subject | wastewater-based epidemiology | ca_CA |
dc.subject | antibiotic resistance | ca_CA |
dc.subject | (fluoro) quinolones | ca_CA |
dc.subject | biomarkers | ca_CA |
dc.title | Enantiomeric profiling of quinolones and quinolones resistance gene qnrS in European wastewaters | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.watres.2020.115653 | |
dc.relation.projectID | This work was supported by the European Union’s SeventhFramework Programme for Research, Technological Developmentand Demonstration [grant agreement 317205, the SEWPROF MCITN project,‘A new paradigm in drug use and human health riskassessment: Sewage profiling at the community level’] and byNatural Environment Research Council Project on‘Impact of ste-reochemistry of antimicrobial agents on their environmental fate,biological potency and the emergence of resistance’[grant NE/N019261/1]. Wastewater samples were provided by local WWTPsto the University of Bath (United Kingdom) by: Wessex Water,Norwegian Institute for Water Research (Norway), Swiss FederalInstitute of Aquatic Science and Technology (Switzerland), Tech-nical University of Denmark (Denmark), Mario Negri Institute forPharmacological Research (Italy), KWR Watercycle Research Insti-tute (The Netherlands), University Jaume I (Spain). ErikaCastrignan o and Barbara Kasprzyk-Hordern planned and designedthe study. Erika Castrignan o, Zhugen Yang, Richard Bade, SaraCastiglioni, Ana Causanilles, Emma Gracia-Lor, Felix Hernandez,Benedek G. Pl osz, Pedram Ramin, Nikolaos I. Rousis, Yeonsuk Ryu,Kevin V Thomas, Pim de Voogt, Ettore Zuccato and BarbaraKasprzyk-Hordern organised the collection of the wastewatersamples. Erika Castrignan o prepared and analysed the samples.Erika Castrignan o and Barbara Kasprzyk-Hordern interpreted theresults, drafted the manuscript, which was critically revised by allco-authors. Jose A. Baz-Lomba from Norwegian Institute for Water esearch (NIVA), Christoph Ort and Ann-Katrin McCall from Eawagare acknowledged for help with sample provision. | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | https://www.sciencedirect.com/science/article/pii/S0043135420301895 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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