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Central neurogenetic signatures of the visuomotor integration system
dc.contributor.author | Bueichekú, Elisenda | |
dc.contributor.author | Aznarez-Sanado, Maite | |
dc.contributor.author | Diez, Ibai | |
dc.contributor.author | d'Oleire Uquillas, Federico | |
dc.contributor.author | Ortiz-Terán, Laura | |
dc.contributor.author | Qureshi, Abid Y. | |
dc.contributor.author | Suñol, Maria | |
dc.contributor.author | Basaia, Silvia | |
dc.contributor.author | Ortiz-Terán, Elena | |
dc.contributor.author | Pastor, Maria A. | |
dc.contributor.author | Sepulcre, Jorge | |
dc.date.accessioned | 2020-04-15T11:43:06Z | |
dc.date.available | 2020-04-15T11:43:06Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Elisenda Bueichekú, Maite Aznárez-Sanado, Ibai Diez, Federico d’Oleire Uquillas, Laura Ortiz-Terán, Abid Y. Qureshi, Maria Suñol, Silvia Basaia, Elena Ortiz-Terán, Maria A. Pastor, Jorge Sepulcre. Central neurogenetic signatures of the visuomotor integration system. Proceedings of the National Academy of Sciences. Mar 2020, 117 (12) 6836-6843; DOI: 10.1073/pnas.1912429117 | ca_CA |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | http://hdl.handle.net/10234/187482 | |
dc.description.abstract | Visuomotor impairments characterize numerous neurological disorders and neurogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Prader–Willi, Turner, and Williams syndromes. Despite recent advances in systems neuroscience, the biological basis underlying visuomotor functional impairments associated with these clinical conditions is poorly understood. In this study, we used neuroimaging connectomic approaches to map the visuomotor integration (VMI) system in the human brain and investigated the topology approximation of the VMI network to the Allen Human Brain Atlas, a whole-brain transcriptome-wide atlas of cortical genetic expression. We found the genetic expression of four genes—TBR1, SCN1A, MAGEL2, and CACNB4—to be prominently associated with visuomotor integrators in the human cortex. TBR1 gene transcripts, an ASD gene whose expression is related to neural development of the cortex and the hippocampus, showed a central spatial allocation within the VMI system. Our findings delineate gene expression traits underlying the VMI system in the human cortex, where specific genes, such as TBR1, are likely to play a central role in its neuronal organization, as well as on specific phenotypes of neurogenetic syndromes. | ca_CA |
dc.format.extent | 8 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | National Academy of Sciences | ca_CA |
dc.relation.isPartOf | Proceedings of the National Academy of Sciences, 2020, vol. 117, no 12 | ca_CA |
dc.rights | Copyright © National Academy of Sciences | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | visuomotor integration | ca_CA |
dc.subject | TBR1 | ca_CA |
dc.subject | brain functional networks | ca_CA |
dc.subject | functional connectivity | ca_CA |
dc.subject | genetics | ca_CA |
dc.title | Central neurogenetic signatures of the visuomotor integration system | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1073/pnas.1912429117 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.pnas.org/content/117/12/6836.short | ca_CA |
dc.contributor.funder | Acknowledgement: This research was supported by grants from the National Institutes of Health (NIH) (K23EB019023, R01AG061811, and R01AG061445 to J.S.). J.S. has no disclosures to report. E.B. was funded by a research stay grant from the Spanish Government (2017 José Castillejo for young Ph.D. researchers) and a postdoctoral research grant from the Generalitat Valenciana and the European Social Fund (“Investing in your future”; 2018 APOSTD). | ca_CA |
dc.type.version | info:eu-repo/semantics/submittedVersion | ca_CA |
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