Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia
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Título
Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced AnergiaAutoría
Fecha de publicación
2020-01-30Editor
Frontiers MediaCita bibliográfica
CARRATALÁ ROS, Carla; LÓPEZ CRUZ, Laura; SAN MIGUEL SEGURA, Noemí; IBÁÑEZ-MARÍN, Patricia; MARTÍNEZ VERDÚ, Andrea; SALAMONE, John D.; CORREA SANZ, Mercé (2020). Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia. Frontiers in Behavioral Neuroscience, v. 13,art. 289Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.frontiersin.org/articles/10.3389/fnbeh.2019.00289/fullVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Physical activities can have intrinsic motivational or reinforcing properties. The choice
to engage in voluntary physical activity is undertaken in relation to the selection of
other alternatives, such as sedentary ... [+]
Physical activities can have intrinsic motivational or reinforcing properties. The choice
to engage in voluntary physical activity is undertaken in relation to the selection of
other alternatives, such as sedentary behaviors, drugs, or food intake. The mesolimbic
dopamine (DA) system plays a critical role in behavioral activation or exertion of effort,
and DA antagonism or depletion induces anergia in effort-based decision-making
tasks. However, little is known about the neural mechanisms underlying the decisionmaking
processes that establish preferences for sedentary vs. activity-based reinforcers.
In the present work with male CD1 mice, we evaluated the effect of tetrabenazine
(TBZ), a DA-depleting agent, on a three-choice T-maze task developed to assess
preference between reinforcers with different behavioral activation requirements and
sensory properties [i.e., a running wheel (RW) vs. sweet pellets or a neutral nonsocial
odor]. We also studied the effects of TBZ on the forced swim test (FST), which measures
climbing and swimming in a stressful setting, and on anxiety tests [dark-light (DL) box
and elevated plus maze (EPM)]. In the three-choice task, TBZ reduced time running in the
wheel but increased time spent consuming sucrose, thus indicating reduced activation
but relatively intact sucrose reinforcement. The effect of TBZ was not mimicked by
motivational manipulations that change the value of the reinforcers, such as making the
RW aversive or harder to move, food-restricting the animals, inducing a binge-like eating
pattern, or introducing social odors. In the FST, TBZ decreased time climbing (most
active behavior) and increased immobility but did not affect anxiety in the DL or EPM.
These results indicate that the three-choice T-maze task could be useful for assessing
DA modulation of preferences for exercise based on activation and effort requirements,
differentiating those effects from changes in preference produced by altering physical
requirements, food restriction state, and stress during testing. [-]
Publicado en
Frontiers in Behavioral Neuroscience (2020), v. 13Proyecto de investigación
1) Grant from Ministerio de Ciencia, Investigación y Universidades (PSI2015-68497-R), Spain, and by NIH/NIMH (R03MH094966-01A1); 2) Personal fellowships were awarded (FPI BES-2016-077177), Ministerio de Economía y Competitividad; 3) (FPU AP2010- 3793), Ministerio de Educación; 4) (PREDOC/2012/28), Universitat Jaume I.Derechos de acceso
info:eu-repo/semantics/openAccess
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