The Arabidopsis thaliana N-recognin E3 ligase PROTEOLYSIS1 influences the immune response
Ver/ Abrir
Impacto
Scholar |
Otros documentos de la autoría: Till, Christopher; Vicente, Jorge; Zhang, Hongtao; Oszvald, Maria; Deery, Michael J.; Pastor, Victoria; Lilley, Kathryn; Ray, Rumiana; Theodoulou, Frederica L.; Holdsworth, Michael
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2508
comunitat-uji-handle3:10234/6999
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
The Arabidopsis thaliana N-recognin E3 ligase PROTEOLYSIS1 influences the immune responseAutoría
Fecha de publicación
2019Editor
Wiley; American Society of Plant Biologists; Society for Experimental BiologyCita bibliográfica
Till CJ, Vicente J, Zhang H, et al. The Arabidopsis thaliana N-recognin E3 ligase PROTEOLYSIS1 influences the immune response. Plant Direct. 2019;3:1–15. https://doi.org/10.1002/pld3.194Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pld3.194Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
N-degron pathways of ubiquitin-mediated proteolysis (formerly known as the
N-end rule pathway) control the stability of substrate proteins dependent on the
amino-terminal (Nt) residue. Unlike yeast or mammalian ... [+]
N-degron pathways of ubiquitin-mediated proteolysis (formerly known as the
N-end rule pathway) control the stability of substrate proteins dependent on the
amino-terminal (Nt) residue. Unlike yeast or mammalian N-recognin E3 ligases,
which each recognize several different classes of Nt residues, in Arabidopsis thaliana,
N-recognin functions of different N-degron pathways are carried out independently
by PROTEOLYSIS (PRT)1, PRT6, and other unknown proteins. PRT1 recognizes type 2
aromatic Nt-destabilizing residues and PRT6 recognizes type 1 basic residues. These
two N-recognin functions diverged as separate proteins early in the evolution of
plants, before the conquest of the land. We demonstrate that loss of PRT1 function
promotes the plant immune system, as mutant prt1-1 plants showed greater apoplastic resistance than WT to infection by the bacterial hemi-biotroph Pseudomonas
syringae pv tomato (Pst) DC3000. Quantitative proteomics revealed increased accumulation of proteins associated with specific components of plant defense in the
prt1-1 mutant, concomitant with increased accumulation of salicylic acid. The effects of the prt1 mutation were additional to known effects of prt6 in influencing
the immune system, in particular, an observed over-accumulation of pipecolic acid
(Pip) in the double-mutant prt1-1 prt6-1. These results demonstrate a potential role
for PRT1 in controlling aspects of the plant immune system and suggest that PRT1
limits the onset of the defense response via degradation of substrates with type 2
Nt-destabilizing residues. [-]
Publicado en
Plant Direct. 2019;3:1–15Proyecto de investigación
BB/M029441/1, BB/S005293/1, BBS/E/C/000I0420Derechos de acceso
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- CAMN_Articles [568]
El ítem tiene asociados los siguientes ficheros de licencia:
Excepto si se señala otra cosa, la licencia del ítem se describe como: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,
provided the original work is properly cited.
© 2019 The Authors. Plant Direct published by American Society of Plant Biologists, Society for Experimental Biology and John Wiley & Sons Ltd.