The Arabidopsis thaliana N-recognin E3 ligase PROTEOLYSIS1 influences the immune response
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Altres documents de l'autoria: Till, Christopher; Vicente, Jorge; Zhang, Hongtao; Oszvald, Maria; Deery, Michael J.; Pastor, Victoria; Lilley, Kathryn; Ray, Rumiana; Theodoulou, Frederica L.; Holdsworth, Michael
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Títol
The Arabidopsis thaliana N-recognin E3 ligase PROTEOLYSIS1 influences the immune responseAutoria
Data de publicació
2019Editor
Wiley; American Society of Plant Biologists; Society for Experimental BiologyCita bibliogràfica
Till CJ, Vicente J, Zhang H, et al. The Arabidopsis thaliana N-recognin E3 ligase PROTEOLYSIS1 influences the immune response. Plant Direct. 2019;3:1–15. https://doi.org/10.1002/pld3.194Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pld3.194Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
N-degron pathways of ubiquitin-mediated proteolysis (formerly known as the
N-end rule pathway) control the stability of substrate proteins dependent on the
amino-terminal (Nt) residue. Unlike yeast or mammalian ... [+]
N-degron pathways of ubiquitin-mediated proteolysis (formerly known as the
N-end rule pathway) control the stability of substrate proteins dependent on the
amino-terminal (Nt) residue. Unlike yeast or mammalian N-recognin E3 ligases,
which each recognize several different classes of Nt residues, in Arabidopsis thaliana,
N-recognin functions of different N-degron pathways are carried out independently
by PROTEOLYSIS (PRT)1, PRT6, and other unknown proteins. PRT1 recognizes type 2
aromatic Nt-destabilizing residues and PRT6 recognizes type 1 basic residues. These
two N-recognin functions diverged as separate proteins early in the evolution of
plants, before the conquest of the land. We demonstrate that loss of PRT1 function
promotes the plant immune system, as mutant prt1-1 plants showed greater apoplastic resistance than WT to infection by the bacterial hemi-biotroph Pseudomonas
syringae pv tomato (Pst) DC3000. Quantitative proteomics revealed increased accumulation of proteins associated with specific components of plant defense in the
prt1-1 mutant, concomitant with increased accumulation of salicylic acid. The effects of the prt1 mutation were additional to known effects of prt6 in influencing
the immune system, in particular, an observed over-accumulation of pipecolic acid
(Pip) in the double-mutant prt1-1 prt6-1. These results demonstrate a potential role
for PRT1 in controlling aspects of the plant immune system and suggest that PRT1
limits the onset of the defense response via degradation of substrates with type 2
Nt-destabilizing residues. [-]
Publicat a
Plant Direct. 2019;3:1–15Proyecto de investigación
BB/M029441/1, BB/S005293/1, BBS/E/C/000I0420Drets d'accés
info:eu-repo/semantics/openAccess
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© 2019 The Authors. Plant Direct published by American Society of Plant Biologists, Society for Experimental Biology and John Wiley & Sons Ltd.