Perineuronal Net Formation and the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate Nucleus
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Otros documentos de la autoría: Mirzadeh, Zaman; Alonge, Kimberly; Cabrales, Elaine; Herranz-Pérez, Vicente; Scarlett, Jarrad M.; Brown, Jenny M.; Hassouna, Rim; Matsen, Miles E.; Nguyen, Hong T.; García-Verdugo, Jose Manuel; Zeltser, Lori; Schwartz, Michael
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INVESTIGACIONMetadatos
Título
Perineuronal Net Formation and the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate NucleusAutoría
Fecha de publicación
2019Editor
Nature ResearchISSN
2522-5812Cita bibliográfica
Mirzadeh, Z., Alonge, K.M., Cabrales, E. et al. Perineuronal net formation during the critical period for neuronal maturation in the hypothalamic arcuate nucleus. Nat Metab 1, 212–221 (2019). https://doi.org/10.1038/s42255-018-0029-0Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.nature.com/articles/s42255-018-0029-0#author-informationVersión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
In leptin-deficient ob/ob mice, obesity and diabetes are associated with abnormal development of neurocircuits in the hypothalamic arcuate nucleus (ARC)1, a critical brain area for energy and glucose homoeostasis2,3. ... [+]
In leptin-deficient ob/ob mice, obesity and diabetes are associated with abnormal development of neurocircuits in the hypothalamic arcuate nucleus (ARC)1, a critical brain area for energy and glucose homoeostasis2,3. Because this developmental defect can be remedied by systemic leptin administration, but only if given before postnatal day 28, a critical period for leptin-dependent development of ARC neurocircuits has been proposed4. In other brain areas, critical-period closure coincides with the appearance of perineuronal nets (PNNs), extracellular matrix specializations that restrict the plasticity of neurons that they enmesh5. Here we report that in humans and rodents, subsets of neurons in the mediobasal aspect of the ARC are enmeshed in PNN-like structures. In mice, these neurons are densely packed into a continuous ring that encircles the junction of the ARC and median eminence, which facilitates exposure of ARC neurons to the circulation. Most of the enmeshed neurons are both γ-aminobutyric acid-ergic and leptin-receptor positive, including a majority of Agouti-related-peptide neurons. Postnatal formation of the PNN-like structures coincides precisely with closure of the critical period for maturation of Agouti-related-peptide neurons and is dependent on input from circulating leptin, because postnatal ob/ob mice have reduced ARC PNN-like material that is restored by leptin administration during the critical period. We conclude that neurons crucial to metabolic homoeostasis are enmeshed in PNN-like structures and organized into a densely packed cluster situated circumferentially at the ARC–median eminence junction, where metabolically relevant humoral signals are sensed. [-]
Publicado en
Nature Metabolism volume 1, pages 212–221 (2019).Proyecto de investigación
DK108596, DK114474, DK083042, DK090320, DK101997, 7-11-BS-179, 18-0025-30-05Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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