Synthesis and biological evaluation of multitarget anticancer compounds
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Título
Synthesis and biological evaluation of multitarget anticancer compoundsAutoría
Tutor/Supervisor; Universidad.Departamento
Carda Usó, Pedro Miguel; Universitat Jaume I. Departament de Química Inorgànica i OrgànicaFecha de publicación
2019-07Editor
Universitat Jaume IResumen
Nowadays, cancer is one of the main health problems in our society. In organic
chemistry, heterocyclic compounds bearing nitrogen atoms are very important for their
pharmaceutical activities, especially for their ... [+]
Nowadays, cancer is one of the main health problems in our society. In organic
chemistry, heterocyclic compounds bearing nitrogen atoms are very important for their
pharmaceutical activities, especially for their anticancer properties. For this reason, the
compounds that present an imidazole ring in their structure could be important in order
to obtain compounds to fight cancer. This structural motif can be found in Nature and is
present in many biomolecules.
There is a need to improve the medications and to find new and more effective
drugs. Docking studies carried out in the research group have shown that certain
compounds containing an imidazole ring can act as c-MYC and PD-L1 dual inhibitors.
The general imidazole structure drawn in figure 6 is based on these docking studies
Therefore, the objectives of this study are:
1. The synthesis of 1-arylmethyl-4-(4-chlorophenyl)-1H-imidazole structures.
2. The biological evaluation of the synthesized compounds as c-MYC and PD-L1
inhibitors. In this sense the following biological activities will be studied:
- Antiproliferative activity
- Inhibition of c-MYC and PD-L1 proteins. [-]
Palabras clave / Materias
Descripción
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2018/2019
Tipo de documento
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- Grau en Química [265]