Abscisic acid Prevents Memory Loss and Neuroinflammation and Increases IRS-2 Expression in Alzheimer’s disease Mice Model

Abstract

Neuroinflammation and insulin resistance in the brain are intimately linked to neurodegenerative disorders, including Alzheimer’s disease. Even though traditionally Alzheimer´s disease has been associated to Ab deposits and hyperphosphorylated Tau intracellular tangles, several studies show that neuroinflammation may be the initial cause that triggers degeneration. Accordingly, a number of natural supplements that improves brain insulin sensitivity and reduce neuroinflammation have been proposed as good choices in therapeutic prevention of cognitive decline. Further supporting this evidence, we show that phytohormone abscisic acid, can prevent memory impairment and neuroinflammation markers in a triple transgenic mouse model (3xTg).