Continuous-flow crystallisation in 3D-printed compact devices

Abstract

A flexible and cost-effective methodology to develop compact flow devices with heat exchange ability is presented here. Additive manufacturing techniques allows the rapid design and manufacturing of modular jacketed flow devices, where heat exchange can be modelled and controlled to generate efficient devices for applications in continuous-flow cooling crystallisation. As a proof of concept, the crystallisation of paracetamol has been demonstrated. The manufactured devices are effective to crystallise form II paracetamol employing metacetamol as co-crystallising agent.