Activity of the oxytocinergic nuclei in the maternal brain
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Título
Activity of the oxytocinergic nuclei in the maternal brainTutor/Supervisor; Universidad.Departamento
Martínez-García, Fernando; Universitat Jaume I. Unitat Predepartamental de Medicina.Fecha de publicación
2019-04-15Editor
Universitat Jaume IResumen
In several mammals and nonmammalian species, oxytocin (OT) has been shown to play a
crucial role in the control of social interactions including maternal behaviours. Maternal care is
especially important, since it ... [+]
In several mammals and nonmammalian species, oxytocin (OT) has been shown to play a
crucial role in the control of social interactions including maternal behaviours. Maternal care is
especially important, since it facilitates not just nurturing and thermoregulation of the offspring,
but also an appropriate neurodevelopment that promotes physical and mental health of the
infants throughout their life. That’s why we are studying maternal behaviours. We use mice,
which have become a good model for research of the neurobiology of maternal care and its
disorders, because they show a neuroendocrinological control of maternal behaviour similar to
humans.
Maternal behaviour is controlled by the socio-sexual brain network (SBN), which is targeted by
projections of oxytocinergic (among others) cells located in the bed nucleus of the stria
terminalis (BSTMPM), the preoptic area (the so-called AC/ADP region) and the paraventricular
(Pa) and supraoptic hypothalamic nuclei (SON). That way, oxytocin modulates SBN activity
during motherhood to facilitate maternal care of pups. Therefore, we analysed the
immunoreactivity for oxytocin and for c-FOS (a good marker for neuronal activity) in these brain
centres of dams and pup-sensitized virgin female mice (godmothers), after being exposed to
pups or to a non-social control stimulus (buttons). The results indicate that there are not
significant differences between dams and godmothers in any of the observed variables. The
only exception was a higher neural activity of the Pa nucleus in dams than in godmothers,
irrespective of the stimuli they had been exposed to. Furthermore, the activity (density of c-FOS
immunoreactive cells) in the analysed brain areas shows distinct patterns of correlation in the
different experimental groups. This suggests that there are functional differences in the circuitry
of maternal behaviour in female mice, which need to be studied in the future in order to
understand how the maternal behaviour is regulated. [-]
Palabras clave / Materias
Descripción
Treball Final de Grau en Medicina. Codi: MD1158. Curs acadèmic: 2018/2019.
Tipo de documento
info:eu-repo/semantics/bachelorThesisDerechos de acceso
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Aparece en las colecciones
- Grau en Medicina [494]