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Synthesis and biological evaluation of potential anticancer drugs
dc.contributor.author | Ibañez-Ibañez, Laura | |
dc.contributor.other | Carda Usó, Pedro Miguel | |
dc.contributor.other | Universitat Jaume I. Departament de Química Inorgànica i Orgànica | |
dc.date.accessioned | 2019-12-02T12:57:32Z | |
dc.date.available | 2019-12-02T12:57:32Z | |
dc.date.issued | 2019-06 | |
dc.identifier.uri | http://hdl.handle.net/10234/185285 | |
dc.description | Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2018/2019 | ca_CA |
dc.description.abstract | Imidazole is an important heterocyclic ring present in several natural products. In the field of medicinal chemistry, the incorporation of the imidazole nucleus is turning an important synthetic strategy in drug discovery, as some imidazole related drugs have shown high chemotherapeutic properties. However, more research is needed to obtain new and more effective anticancer drugs. Thus, the aims of the present work include the synthesis of some 4-(4-bromophenyl)-1-arylmethyl-1H-imidazoles as well as their biological evaluation. Specifically, the objectives of the current study were: I. The synthesis of 4-(4-bromophenyl)-1-methylbenzyl-1H-imidazoles and 4-(4- bromophenyl)-1-methoxybenzyl-1H-imidazoles, whose general structure is depicted in Figure 6. Figure 6. Structure of 4-(4-bromophenyl)-1-arylmethyl-1H-imidazoles. II. The biological evaluation of the above-mentioned compounds as regards: a) Their antiproliferative activity. b) Their activity on the inhibition of c-MYC and PD-L1 proteins | ca_CA |
dc.format.extent | 69 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Universitat Jaume I | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Grau en Química | ca_CA |
dc.subject | Grado en Química | ca_CA |
dc.subject | Bachelor's Degree in Chemistry | ca_CA |
dc.title | Synthesis and biological evaluation of potential anticancer drugs | ca_CA |
dc.type | info:eu-repo/semantics/bachelorThesis | ca_CA |
dc.educationLevel | Estudios de Grado | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
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