Role of AMPA glutamate receptors in the conditioned rewarding effects of MDMA in mice
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https://doi.org/10.1016/j.bbr.2018.03.010 |
Metadatos
Título
Role of AMPA glutamate receptors in the conditioned rewarding effects of MDMA in miceFecha de publicación
2018-07-16Editor
ElsevierISSN
0166-4328Cita bibliográfica
GARCÍA-PARDO, M. P.; MIÑARRO, J.; AGUILAR, M. A. Role of AMPA glutamate receptors in the conditioned rewarding effects of MDMA in mice. Behavioural brain research, 2018, vol. 347, p. 57-60Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S0166432817318077Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Currently, there is not an effective treatment for 3,4-methylenedioxymethamphetamine (MDMA) dependence but pharmacotherapies targeting glutamate neurotransmission are a promising strategy. Previously, we showed that ... [+]
Currently, there is not an effective treatment for 3,4-methylenedioxymethamphetamine (MDMA) dependence but pharmacotherapies targeting glutamate neurotransmission are a promising strategy. Previously, we showed that blockade of glutamate NMDA and AMPA receptors impairs the conditioned rewarding effects of MDMA and cocaine, respectively. In this study we evaluated the role of AMPA receptors in the rewarding effects of MDMA in mice using the conditioned place preference (CPP) paradigm. Mice were conditioned with MDMA (1.25 mg/kg) 60 min after the treatment with saline or different doses (0.25, 1 and 5 mg/kg) of the AMPA/kainate receptor antagonist, 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). Mice conditioned with MDMA acquired CPP while those treated with any dose of CNQX + MDMA did not. These results supported the involvement of the glutamatergic system in the rewarding properties of MDMA, and suggest that AMPA receptor blockade could be a new therapeutic option for the treatment of those individuals that develop MDMA dependence. [-]
Publicado en
Behavioural brain research, 2018, vol. 347Proyecto de investigación
Ministerio de Economia y Competitividad (MINECO); Direccion General de Investigation: PSI2014-51847; PSI2017-83023-R; Institute de Salud Carlos III; Red de Trastornos Adictivos (RTA): RD12/0028/0005; RD16/0017/0007; Union Europea, Fondos FEDER "una manera de hacer Europa"Derechos de acceso
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