Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial
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https://doi.org/10.1093/ije/dyy225 |
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Título
Cohort Profile: Design and methods of the PREDIMED-Plus randomized trialAutoría
Fecha de publicación
2019-04Editor
Oxford University PressCita bibliográfica
MARTÍNEZ-GONZÁLEZ, Miguel A., et al. Cohort Profile: Design and methods of the PREDIMED-Plus randomized trial. International journal of epidemiology, 2019, 48.2: 387–388.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://academic.oup.com/ije/article/48/2/387/5202210?searchresult=1Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The PREDIMED (in Spanish: PREvención con DIeta MEDiterránea) primary prevention trial1–3 reported in 2013 that long-term adherence to an energy-unrestricted Mediterranean diet (MedDiet), supplemented with either ... [+]
The PREDIMED (in Spanish: PREvención con DIeta MEDiterránea) primary prevention trial1–3 reported in 2013 that long-term adherence to an energy-unrestricted Mediterranean diet (MedDiet), supplemented with either extra-virgin olive oil (EVOO) or nuts, reduced cardiovascular disease (CVD). PREDIMED showed a 30% relative reduction in the composite cardiovascular primary endpoint (stroke, myocardial infarction or cardiovascular death).2,,3 However, the PREDIMED trial tested only the composition of the diet, but did not test other lifestyle interventions (i.e. energy reduction, increased physical activity (PA) and behavioural modification) frequently applied in the context of the current unprecedented obesity pandemic.4,,5 With the exception of the null results of the Look-AHEAD trial,6 and the successful results of the EXERDIET-HTA study that found improvements in blood pressure, cardio-respiratory fitness and body composition (though they encouraged adherence to an hypocaloric DASH diet, instead of a Mediterranean diet),7 lifestyle interventions including such components have never been tested in long-term randomized trials using hard cardiovascular events as endpoints. [-]
Proyecto de investigación
European Research Council (Advanced Research Grant 2014–2019; agreement #340918 granted to MAM-G), and the Spanish Government Official Agency for funding biomedical research - Instituto de Salud Carlos III (ISCIII), with competitive grants for the periods 2014–16, 2015–17, 2017–19 and 2018–20, through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (grants: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926). Additional grants: Acciones Especiales from ISCIIII, Consejería-Salud, Junta de Andalucía (PI0458/2013, PS0358/2016), Recercaixa-grant 2013 (2013ACUP00194), and a SEMERGEN grant.Derechos de acceso
Copyright © 2019 Oxford University Press
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http://rightsstatements.org/vocab/InC/1.0/
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