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Arylpyridines, arylpyrimidines and related compounds as potential modulator agents of the VEGF, hTERT and c-Myc oncogenes
dc.contributor.author | Martín Beltrán, Celia | |
dc.contributor.author | Sanchez Peris, Maria | |
dc.contributor.author | Conesa Milián, Laura | |
dc.contributor.author | Falomir, Eva | |
dc.contributor.author | Murga, Juan | |
dc.contributor.author | Carda, Miguel | |
dc.contributor.author | Alberto Marco, J. | |
dc.date.accessioned | 2019-05-13T10:03:23Z | |
dc.date.available | 2019-05-13T10:03:23Z | |
dc.date.issued | 2019-03-01 | |
dc.identifier.citation | MARTÍN-BELTRÁN, Celia, et al. Arylpyridines, arylpyrimidines and related compounds as potential modulator agents of the VEGF, hTERT and c-Myc oncogenes. Bioorganic & medicinal chemistry, 2019, vol. 27, no 5, p. 880-887 | ca_CA |
dc.identifier.issn | 0968-0896 | |
dc.identifier.issn | 1464-3391 | |
dc.identifier.uri | http://hdl.handle.net/10234/182475 | |
dc.description.abstract | Twenty-four derivatives structurally related to honokiol have been synthesized and biologically evaluated. IC50 values were determined towards the HT-29, MCF-7 and HEK-293 cell lines. Some of these derivatives exhibited comparable or lower IC50 values than honokiol towards the HT-29 and MCF-7 cell lines or else higher selectivity indexes than the natural product. Twelve selected derivatives were evaluated for their ability to inhibit the expression of the VEGFA, hTERT and c-Myc genes and also to inhibit the production of total c-Myc protein and the secretion of the VEGF protein. One of the most promising compounds, 3-(2,4-dimethoxyphenyl)pyridine, may be a good candidate for further studies as an anticancer agent as it is able to improve the effect shown by honokiol in downregulating all gene expression and protein production at a safe concentration for non-tumor cells. | ca_CA |
dc.format.extent | 8 p. | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Bioorganic & medicinal chemistry, 2019, vol. 27, no | ca_CA |
dc.rights | Copyright © Elsevier B.V. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | anticancer agents | ca_CA |
dc.subject | antiproliferative activity | ca_CA |
dc.subject | aza and diazabiphenyl derivatives | ca_CA |
dc.subject | gene targeting | ca_CA |
dc.title | Arylpyridines, arylpyrimidines and related compounds as potential modulator agents of the VEGF, hTERT and c-Myc oncogenes | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.bmc.2019.01.039 | |
dc.relation.projectID | Ministerio de Economia y Competitividad of Spain: CTQ2014-52949-P; Conselleria dEmpresa, Universitat i Ciencia de la Generalitat Valenciana: PROMETEO/2013/027, ACOMP/2014/274; University Jaume I: PI-1B2011-37 | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | https://www.sciencedirect.com/science/article/pii/S0968089618318881 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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