Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants
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Other documents of the author: Palla-Rubio, B.; Gomes, Nuno; Fernández Gutiérrez, Mar; Rojo, Luis; Suay, Julio; Gurruchaga, Mariló; Goñi, Isabel
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7034
comunitat-uji-handle3:10234/8619
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INVESTIGACIONMetadata
Title
Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implantsAuthor (s)
Date
2019-01Publisher
ElsevierISSN
0144-8617; 1879-1344Bibliographic citation
PALLA-RUBIO, B., et al. Synthesis and characterization of silica-chitosan hybrid materials as antibacterial coatings for titanium implants. Carbohydrate polymers, 2019, vol. 203, p. 331-341Type
info:eu-repo/semantics/articlePublisher version
https://www.sciencedirect.com/science/article/pii/S014486171831138XVersion
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Abstract
To avoid dental implant-related infections and to promote the osseointegration of titanium implants, the application of silicon and chitosan containing coatings is proposed. Silicon is a well-known osteogenic element ... [+]
To avoid dental implant-related infections and to promote the osseointegration of titanium implants, the application of silicon and chitosan containing coatings is proposed. Silicon is a well-known osteogenic element and chitosan was selected to confer the antibacterial properties. The synthesis of hybrid silica-chitosan coatings using the sol-gel process is presented and the characterization using 29Si-NMR to verify the correct formation of the network is discussed. The 13C NMR spectroscopy was used to confirm the covalent union between chitosan and the silicon network. Hydrolytic degradation and silicon release studies showed the effective silicon release from the hybrids and, hence, the possibility to promote bone formation. The introduction of different amounts of chitosan and tetraethyl orthosilicate (TEOS) modulated the Si release. The analysis of cell cultures in vitro demonstrated that the hybrid coatings were not cytotoxic and promoted cell proliferation on their surfaces. The coatings containing 5%–10% chitosan had substantial antibacterial properties. [-]
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Carbohydrate polymers, 2019, vol. 203Rights
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