New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration
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Other documents of the author: Kaneko, Naoko; Herranz-Pérez, Vicente; Otsuka, Takanobu; Sano, H.; Ohno, N.; Omata, T.; Nguyen, Huy Bang; Thai, T.Q.; Nambu, A.; Kawaguchi, Yuki; García-Verdugo, Jose Manuel; Sawamoto, Kazunobu
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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INVESTIGACIONMetadata
Title
New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regenerationAuthor (s)
Date
2018Publisher
American Association for the Advancement of ScienceISSN
2375-2548Bibliographic citation
Kaneko, N., et al. "New neurons use Slit-Robo signaling to migrate through the glial meshwork and approach a lesion for functional regeneration." Science advances, 2018, vol. 4, núm. 12Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionAbstract
After brain injury, neural stem cell–derived neuronal precursors (neuroblasts) in the ventricular-subventricular zone migrate toward the lesion. However, the ability of the mammalian brain to regenerate ... [+]
After brain injury, neural stem cell–derived neuronal precursors (neuroblasts) in the ventricular-subventricular zone migrate toward the lesion. However, the ability of the mammalian brain to regenerate neuronal circuits for functional recovery is quite limited. Here, using a mouse model for ischemic stroke, we show that neuroblast mi-gration is restricted by reactive astrocytes in and around the lesion. To migrate, the neuroblasts use Slit1-Robo2 signaling to disrupt the actin cytoskeleton in reactive astrocytes at the site of contact. Slit1-overexpressing neu-roblasts transplanted into the poststroke brain migrated closer to the lesion than did control neuroblasts. These neuroblasts matured into striatal neurons and efficiently regenerated neuronal circuits, resulting in functional recovery in the poststroke mice. These results suggest that the positioning of new neurons will be critical for func-tional neuronal regeneration in stem/progenitor cell–based therapies for brain injury. [-]
Investigation project
This work was supported by research grants from NEXT (LS104), MEXT KAKENHI [22122004, 17H05750, and 17H05512 (to K.S.) and 15H05873 (to A.N.)], JSPS KAKENHI [26250019, 17H01392, and JP16H06280 (to K.S.); 25111727, 23680041, and 17K07114 (to N.K.); and 26250009 (to A.N.)], the JSPS Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers [S2704 (to N.K., V.H.-P., J.M.G.-V., and K.S.)], the Brain Science Foundation (to N.K.), a Grant-in-Aid for Research at Nagoya City University (to N.K. and K.S.), GVA PrometeoII/2014/075 (to J.M.G.-V.), TerCel ISCIII2012-RED-19-016 (to J.M.G.-V.), the Takeda Science Foundation (to K.S.), and the Cooperative Study Programs of the National Institute for Physiological Sciences (to N.K. and K.S.).Rights
info:eu-repo/semantics/openAccess
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Except where otherwise noted, this item's license is described as Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S.Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC)