The role of the cerebellum in drug-cue associative memory: functional interactions with the medial prefrontal cortex
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Altres documents de l'autoria: Gil-Miravet, Isis; Guarque-Chabrera, Julian; Carbó Gas, María; Olucha-Bordonau, Francisco E; MIQUEL, MARTA
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The role of the cerebellum in drug-cue associative memory: functional interactions with the medial prefrontal cortexAutoria
Data de publicació
2018-10-02Editor
John Wiley; Federation of European Neuroscience SocietieCita bibliogràfica
GIL-MIRAVET, isis; GUARQUQE-CHABRERA, Julian; CARBÓ GAS, María; OLUCHA-BORDONAU, Francisco E; MIQUEL, Marta (2018). The role of the cerebellum in drug-cue associative memory: functional interactions with the medial prefrontal cortex. European Journal of Neuroscience, onlineTipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.14187Versió
info:eu-repo/semantics/sumittedVersionParaules clau / Matèries
Resum
Drug-induced Pavlovian memories are thought to be crucial for drug addiction because they guide behaviour towards environments
with drug availability. Drug-related memory depends on persistent changes in dopamine-g ... [+]
Drug-induced Pavlovian memories are thought to be crucial for drug addiction because they guide behaviour towards environments
with drug availability. Drug-related memory depends on persistent changes in dopamine-glutamate interactions in the medial pre-
frontal cortex (mPFC), basolateral amygdala, nucleus accumbens core and hippocampus. Recent evidence from our laboratory indi-
cated that the cerebellum is also a relevant node for drug-cue associations. In the present study, we tested the role that specific
regions of the cerebellum and mPFC play in the acquisition of cocaine-induced preference conditioning. Quinolinic acid was used to
manage a permanent deactivation of lobule VIII in the vermis prior to conditioning. Additionally, lidocaine was infused into the prelim-
bic and infralimbic (IL) cortices for reversible deactivation before every training session. The present findings show, for the first time,
that the cerebellum and mPFC might act together in order to acquire drug-cue Pavlovian associations. Either a dorsal lesion in lobule
VIII or an IL deactivation encouraged cocaine-induced preference conditioning. Moreover, simultaneous IL-cerebellar deactivation
prevented the effect of either of the separate deactivations. Therefore, similar to the IL cortex, neural activity in the cerebellum may
be crucial for ensuring inhibitory control of the expression of cocaine-related memories. [-]
Publicat a
European Journal of Neuroscience (2018), onlineProyecto de investigación
1) Ministerio de Educación,Cultura y Deporte (FPU12/04059); 2) Universitat Jaume I (PREDOC2014/11); 3) UJI (14I307.01/1); 4) Ministerio de Economía y Competitividad (MINECO) (PSI2015-68600-P); 5) Plan Nacional de Drogas 2017 (PND-132400)Drets d'accés
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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