Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect
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Other documents of the author: Corella, Dolores; Coltell, Oscar; Macian, Fernando; Ordovás Muñoz, José M.
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7038
comunitat-uji-handle3:10234/8634
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Title
Advances in Understanding the Molecular Basis of the Mediterranean Diet EffectDate
2018Publisher
Annual ReviewsISSN
1941-1413; 1941-1421Bibliographic citation
CORELLA, Dolores, et al. Advances in Understanding the Molecular Basis of the Mediterranean Diet Effect. Annual review of food science and technology, 2018, vol. 9, p. 227-249Type
info:eu-repo/semantics/articlePublisher version
https://www.annualreviews.org/doi/abs/10.1146/annurev-food-032217-020802Version
info:eu-repo/semantics/submittedVersionSubject
Abstract
Increasingly, studies showing the protective effects of the Mediterranean diet (MedDiet) on different diseases (cardiovascular, diabetes, some cancers, and even total mortality and aging indicators) are being published. ... [+]
Increasingly, studies showing the protective effects of the Mediterranean diet (MedDiet) on different diseases (cardiovascular, diabetes, some cancers, and even total mortality and aging indicators) are being published. The scientific evidence level for each outcome is variable, and new studies are needed to better understand the molecular mechanisms whereby the MedDiet may exercise its effects. Here, we present recent advances in understanding the molecular basis of MedDiet effects, mainly focusing on cardiovascular diseases but also discussing other related diseases. There is heterogeneity in defining the MedDiet, and it can, owing to its complexity, be considered as an exposome with thousands of nutrients and phytochemicals. We review MedDiet composition and assessment as well as the latest advances in the genomic, epigenomic (DNA methylation, histone modifications, microRNAs, and other emerging regulators), transcriptomic (selected genes and whole transcriptome), and metabolomic and metagenomic aspects of the MedDiet effects (as a whole and for its most typical food components). We also present a critical review of the limitations of the studies undertaken and propose new analyses and greater bioinformatic integration to better understand the most important molecular mechanisms whereby the MedDiet as a whole, or its main food components, may exercise their protective effects. [-]
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Posted with permission from the Annual Review of Food Science and Technology, Volume 9 by Annual Reviews, http://www.annualreviews.org.
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Annual review of food science and technology, 2018, vol. 9Investigation project
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