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Synthesis and biological evaluation of biaryl compounds as PD-L1 and c-MYC inhibitors
dc.contributor.author | Bou Puerto, Amelia | |
dc.contributor.other | Carda Usó, Pedro Miguel | |
dc.contributor.other | Universitat Jaume I. Departament de Química Inorgànica i Orgànica | |
dc.date.accessioned | 2018-10-02T07:44:40Z | |
dc.date.available | 2018-10-02T07:44:40Z | |
dc.date.issued | 2018-07 | |
dc.identifier.uri | http://hdl.handle.net/10234/176444 | |
dc.description | Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2017/2018 | ca_CA |
dc.description.abstract | The main aim of this project is the search for compounds with dual inhibitory activity on cMYC and PD-L1. Following the recent publication focused on the use of biaryl derivatives as small-molecule inhibitors of cancer-related proteins, the research group I have worked with is carrying out a line of research on the development of derivatives of arylpyridines and arylpyrimidines as chemical inhibitors of c-MYC and PD-L1 proteins. Therefore, it has been decided to synthesize (methoxyphenyl)pyridine and (methoxyphenyl)pyrimidine derivative compounds because previous results obtained within the research group showed that similar biaryl derivatives had significant inhibitory activity on PD-L1 and c-MYC. Thus, the aims of this project are: 1. Synthesis of the biaryl compounds depicted in Figure 12. 2. Biologic evaluation of the selected compounds: 2.1. Study of the antiproliferative activity and cytotoxicity by MTT assay. 2.2. Study of the interaction of compounds with PD-L1 by Protein Thermal Shift assay. 2.3. Study of the effect on c-MYC and PD-L1 in tumor cells by flow cytometry assay. 2.4. Cell co-cultures assays. | ca_CA |
dc.format.extent | 60 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Universitat Jaume I | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Grau en Química | ca_CA |
dc.subject | Grado en Química | ca_CA |
dc.subject | Bachelor's Degree in Chemistry | ca_CA |
dc.title | Synthesis and biological evaluation of biaryl compounds as PD-L1 and c-MYC inhibitors | ca_CA |
dc.type | info:eu-repo/semantics/bachelorThesis | ca_CA |
dc.educationLevel | Estudios de Grado | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
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Grau en Química [265]
QU0943