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Violent aggression predicted by multiple pre-adult environmental hits
dc.contributor.author | Mitjans, Marina | |
dc.contributor.author | Seidel, Jan | |
dc.contributor.author | Begemann, Martin | |
dc.contributor.author | Bockhop, Fabian | |
dc.contributor.author | Moya-Higueras, Jorge | |
dc.contributor.author | Bansal, Vikas | |
dc.contributor.author | Wesolowsk, Janina | |
dc.contributor.author | Seelbach, Anna | |
dc.contributor.author | Ibáñez, Manuel I | |
dc.contributor.author | Kovacevic, Fatka | |
dc.contributor.author | Duvar, Oguzhan | |
dc.contributor.author | Fañanás Saura, Lourdes | |
dc.contributor.author | Wolf, Hannah-Ulrike | |
dc.contributor.author | Ortet, Generós | |
dc.contributor.author | Zwanzger, Peter | |
dc.contributor.author | Klein, Verena | |
dc.contributor.author | Lange, Ina | |
dc.contributor.author | Tänzer, Andreas | |
dc.contributor.author | Dudeck, Manuela | |
dc.contributor.author | Penke, Lars | |
dc.contributor.author | Tebartz van Elst, Ludger | |
dc.contributor.author | Bittner, Robert A. | |
dc.contributor.author | Schmidmeier, Richard | |
dc.contributor.author | Freese, Roland | |
dc.contributor.author | Müller-Isberner, Rüdiger | |
dc.contributor.author | Wiltfang, Jens | |
dc.contributor.author | Bliesener, Thomas | |
dc.contributor.author | Bonn, Stefan | |
dc.contributor.author | Poustka, Luise | |
dc.contributor.author | Müller, Jürgen L. | |
dc.contributor.author | Arias, Barbara | |
dc.contributor.author | Ehrenreich, Hannelore | |
dc.date.accessioned | 2018-07-04T10:28:31Z | |
dc.date.available | 2018-07-04T10:28:31Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1359-4184 | |
dc.identifier.issn | 1476-5578 | |
dc.identifier.uri | http://hdl.handle.net/10234/175458 | |
dc.description.abstract | Early exposure to negative environmental impact shapes individual behavior and potentially contributes to any mental disease. We reported previously that accumulated environmental risk markedly decreases age at schizophrenia onset. Follow-up of matched extreme group individuals (≤1 vs. ≥3 risks) unexpectedly revealed that high-risk subjects had >5 times greater probability of forensic hospitalization. In line with longstanding sociological theories, we hypothesized that risk accumulation before adulthood induces violent aggression and criminal conduct, independent of mental illness. We determined in 6 independent cohorts (4 schizophrenia and 2 general population samples) pre-adult risk exposure, comprising urbanicity, migration, physical and sexual abuse as primary, and cannabis or alcohol as secondary hits. All single hits by themselves were marginally associated with higher violent aggression. Most strikingly, however, their accumulation strongly predicted violent aggression (odds ratio 10.5). An epigenome-wide association scan to detect differential methylation of blood-derived DNA of selected extreme group individuals yielded overall negative results. Conversely, determination in peripheral blood mononuclear cells of histone-deacetylase1 mRNA as ‘umbrella mediator’ of epigenetic processes revealed an increase in the high-risk group, suggesting lasting epigenetic alterations. Together, we provide sound evidence of a disease-independent unfortunate relationship between well-defined pre-adult environmental hits and violent aggression, calling for more efficient prevention. | ca_CA |
dc.format.extent | 16 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Nature Publishing Group | ca_CA |
dc.relation.isPartOf | Molecular Psychiatry (2018) | ca_CA |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | ca_CA |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.title | Violent aggression predicted by multiple pre-adult environmental hits | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1038/s41380-018-0043-3 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.nature.com/articles/s41380-018-0043-3 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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