Subcortical grey matter structures in multiple sclerosis: what is their role in cognition?
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Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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INVESTIGACIONMetadatos
Título
Subcortical grey matter structures in multiple sclerosis: what is their role in cognition?Autoría
Fecha de publicación
2018Editor
Lippincott, Williams & WilkinsISSN
0959-4965; 1473-558XTipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://journals.lww.com/neuroreport/Abstract/2018/05010/Subcortical_grey_matter ...Versión
info:eu-repo/semantics/acceptedVersionPalabras clave / Materias
Resumen
The present study aimed to investigate altered grey matter (GM) and functional
connectivity (FC) in deep subcortical areas, like the thalamus and basal ganglia, and
their relationship with cognitive impairment in ... [+]
The present study aimed to investigate altered grey matter (GM) and functional
connectivity (FC) in deep subcortical areas, like the thalamus and basal ganglia, and
their relationship with cognitive impairment in multiple sclerosis (MS). Thirty-six
patients were neuropsychologically assessed, classified as cognitive preserved (CP) and
cognitive impairment (CI), and were compared with 18 healthy controls (HC). GM
atrophy and FC were observed in 10 predefined functional areas of the thalamus and in
six of basal ganglia. GM atrophy was prominent in the basal ganglia in CI patients
compared to CP MS patients. Increased FC was observed between the right caudate and
the bilateral orbitofrontal cortex in CI vs. CP patients. The discriminant and correlation
analyses revealed that the enhanced FC observed between the right caudate and the
orbitofrontal cortex was closely associated with cognitive impairment in MS patients. In
conclusion, reduced GM volume and enhanced fronto-basal ganglia connectivity are
related to cognition in MS patients. [-]
Publicado en
NeuroReport: May 2, 2018 - Volume 29 - Issue 7Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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