comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
comunitat-uji-handle4:
INVESTIGACION
Metadatos
Título
Bioelectrical Signals and Ion Channels in the Modeling of Multicellular Patterns and Cancer Biophysics
Fecha de publicación
2016
Editor
Nature Publishing Group
ISSN
2045-2322
Cita bibliográfica
CERVERA, Javier; ALCARAZ, Antonio; MAFE, Salvador. Bioelectrical signals and ion channels in the modeling of multicellular patterns and cancer biophysics. Scientific reports, 2016, 6: 20403
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Palabras clave / Materias
Resumen
Bioelectrical signals and ion channels are central to spatial patterns in cell ensembles, a problem
of fundamental interest in positional information and cancer processes. We propose a model for
electrically ... [+]
Bioelectrical signals and ion channels are central to spatial patterns in cell ensembles, a problem
of fundamental interest in positional information and cancer processes. We propose a model for
electrically connected cells based on simple biological concepts:
i
) the membrane potential of a single
cell characterizes its electrical state;
ii
) the long-range electrical coupling of the multicellular ensemble
is realized by a network of gap junction channels between neighboring cells; and
iii
) the spatial
distribution of an external biochemical agent can modify the conductances of the ion channels in a cell
membrane and the multicellular electrical state. We focus on electrical effects in small multicellular
ensembles, ignoring slow diffusional processes. The spatio-temporal patterns obtained for the local
map of cell electric potentials illustrate the normalization of regions with abnormal cell electrical states.
The effects of intercellular coupling and blocking of specific channels on the electrical patterns are
described. These patterns can regulate the electrically-induced redistribution of charged nanoparticles
over small regions of a model tissue. The inclusion of bioelectrical signals provides new insights for
the modeling of cancer biophysics because collective multicellular states show electrical coupling
mechanisms that are not readily deduced from biochemical descriptions at the individual cell level. [-]
Publicado en
Scientific reports, 2016, 6: 20403.
Proyecto de investigación
Financial supports by the Generalitat Valenciana (Program of Excellence Prometeo/GV/0069), the Spanish Ministry of Economic Affairs and Competitiveness (MAT2015-65011-P and FIS2013-40473-P), and FEDER are gratefully acknowledged.
Derechos de acceso
info:eu-repo/semantics/openAccess
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