Osseointegration mechanisms: a proteomic approach
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Other documents of the author: Gomes, Nuno; Romero-Gavilán, Francisco J; García-Arnáez, Iñaki; Martinez Ramos, Cristina; Sánchez-Pérez, Ana María; Azkargorta, Mikel; Elortza, Felix; Martín de Llano, J.J.; GURRUCHAGA, MARILO; Goñi, Isabel; Suay, Julio
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7034
comunitat-uji-handle3:10234/8619
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
Osseointegration mechanisms: a proteomic approachAuthor (s)
Date
2018-03Publisher
Springer-VerlagBibliographic citation
ARAÚJO-GOMES, N., et al. Osseointegration mechanisms: a proteomic approach. JBIC Journal of Biological Inorganic Chemistry, 2018, 1-12.Type
info:eu-repo/semantics/articlePublisher version
https://link.springer.com/content/pdf/10.1007/s00775-018-1553-9.pdfVersion
info:eu-repo/semantics/sumittedVersionSubject
Abstract
The prime objectives in the development of biomaterials for dental applications are to improve the quality of osseointegration
and to short the time needed to achieve it. Design of implants nowadays involves changes ... [+]
The prime objectives in the development of biomaterials for dental applications are to improve the quality of osseointegration
and to short the time needed to achieve it. Design of implants nowadays involves changes in the surface characteristics to
obtain a good cellular response. Incorporating osteoinductive elements is one way to achieve the best regeneration possible
post-implantation. This study examined the osteointegrative potential of two distinct biomaterials: sandblasted acid-etched
titanium and a silica sol–gel hybrid coating, 70% MTMOS-30% TEOS. In vitro, in vivo, and proteomic characterisations of
the two materials were conducted. Enhanced expression levels of ALP and IL-6 in the MC3T3-E1 cells cultured with coated
discs, suggest that growing cells on such surfaces may increase mineralisation levels. 70M30T-coated implants showed
improved bone growth in vivo compared to uncoated titanium. Complete osseointegration was achieved on both. However,
coated implants displayed osteoinductive properties, while uncoated implants demonstrated osteoconductive characteristics.
Coagulation-related proteins attached predominantly to SAE-Ti surface. Surface properties of the material might drive the
regenerative process of the affected tissue. Analysis of the proteins on the coated dental implant showed that few proteins
specifically attached to its surface, possibly indicating that its osteoinductive properties depend on the silicon delivery from
the implant. [-]
Investigation project
MAT2017-86043-R (MINECO); Universidad Jaume I (UJI-B2017-37) (Grant Predoc/2014/25); University of the Basque Country (UPV/EHU) (UFI11/56); Basque Government (IT611-13) and (Grant Predoc/2016/1/0141) ; Generalitat Valenciana (Grant Grisolia/2014/016)Rights
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