Selective synthesis of partial glycerides of conjugated linoleic acids via modulation of the catalytic properties of lipases by immobilization on different supports
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https://doi.org/10.1016/j.foodchem.2017.10.072 |
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Título
Selective synthesis of partial glycerides of conjugated linoleic acids via modulation of the catalytic properties of lipases by immobilization on different supportsAutoría
Fecha de publicación
2018-04-15Editor
ElsevierCita bibliográfica
VERDASCO MARTÍN, Carlos M.; GARCÍA VERDUGO, Eduardo; PORCAR, Raúl; FERNÁNDEZ LAFUENTE, Roberto; OTERO, Cristina. (2018). Selective synthesis of partial glycerides of conjugated linoleic acids via modulation of the catalytic properties of lipases by immobilization on different supports. Food Chemistry, v. 245, p. 39-46Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S0308814617317107Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Lipases B from Candida antarctica (CALB), Rhizomucor miehei (RML) and Thermomyces lanuginosus (TLL) were immobilized on octadecyl methacylate (OM) or octadecyl methacrylate (OMC) beads. Their specific activity and ... [+]
Lipases B from Candida antarctica (CALB), Rhizomucor miehei (RML) and Thermomyces lanuginosus (TLL) were immobilized on octadecyl methacylate (OM) or octadecyl methacrylate (OMC) beads. Their specific activity and regioselectivity were studied in the synthesis of conjugated linoleic acid (CLA) partial glycerides, which presented nutraceutical properties.
TLL derivatives were poor catalysts. Novozym® 435 was much better than Lipozyme® RM IM. RML activity (a GRAS enzyme) was modulated via immobilization. After only 3 h, OM−RML gave the highest CLA conversion (54% at 40 °C with 1:3 M ratio of glycerol to CLA). OM-RML reduced by a factor of 3.12 and 1.16 the activation energy of the reaction with Lipozyme® RM IM and Novozym® 435, respectively.
The new GRAS preparation OM-RML brings forth an optimal regioselective preparation of sn-1 mono and sn-1,3 diacylglycerols rich in CLA, with a ratio of sn-1,3/sn-1,2 regioisomers of 21.8, compared to 2.3 for Novozym® 435. [-]
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Food Chemistry (2018), v. 245Proyecto de investigación
1) Program of I+D Activities of the Autonomous Community of Madrid, Spain: Tecnología 2013 (Project INSPIRA1-CM Ref. S2013/ABI-2783 “Aplicaciones industriales de la Espirulina”., and 2) European Structural Found (European Social Found -EFS- and European Found for Regional Development-FEDER-); 3) Support from the MINECO of Spanish Government, CTQ2013-41507-R and CTQ2017-86170-R.Derechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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