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Sacubitril/valsartan and short-term changes in the 6-minute walk test: A pilot study
dc.contributor.author | Beltrán, Paola | |
dc.contributor.author | Palau, Patricia | |
dc.contributor.author | Domínguez Mafé, Eloy | |
dc.contributor.author | Faraudo, Mercedes | |
dc.contributor.author | Núñez, Eduardo | |
dc.date.accessioned | 2018-03-02T12:21:00Z | |
dc.date.available | 2018-03-02T12:21:00Z | |
dc.date.issued | 2018-02 | |
dc.identifier.citation | BELTRÁN, Paola, et al. Sacubitril/valsartan and short-term changes in the 6-minute walk test: A pilot study. International journal of cardiology, 2018, vol. 252, p. 136-139. | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/173150 | |
dc.description.abstract | Background Impaired exercise capacity is the most disabling symptom in patients with heart failure with reduced ejection fraction (HFrEF). Despite sacubitril/valsartan showing reduced long-term morbidity and mortality over enalapril in HFrEF, its effects on short-term functional capacity remain uncertain. We sought to evaluate the effects of sacubitril/valsartan on a 30-day six-minute walk test in eligible patients with HFrEF. Methods and results From November 1, 2016 to February 1, 2017, a total of 58 stable symptomatic patients with HFrEF were eligible for sacubitril/valsartan and underwent 6-MWT before and 30 days after initiation of sacubitril/valsartan therapy. A mixed-effects model for repeated-measures was used to analyze the changes. Mean age was 70 ± 11 years. 72.4% males, 46.6% with ischemic heart disease, and 51.7% on NYHA functional class III were included. The mean (SD) values of baseline LVEF and 6MWT were 30 ± 7%, and 300 ± 89 m, respectively. The median (IQR) of NT-proBNP at baseline was 2701 pg/ml (1087–4200). Compared with baseline, the 6-MWT distance increased significantly at 30 days by 13.9% (+∆ = 41.8 m (33.4–50.2); p < 0.001). Conclusions In this pilot study, sacubitril/valsartan was associated with an improvement in exercise tolerance in symptomatic patients with HFrEF. | ca_CA |
dc.format.extent | 3 p. | ca_CA |
dc.language.iso | cat | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.rights | Copyright © 2018 Elsevier Inc. All rights reserved. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | heart failure with reduced ejection fraction | ca_CA |
dc.subject | Sacubitril/valsartan | ca_CA |
dc.subject | exercise capacity | ca_CA |
dc.title | Sacubitril/valsartan and short-term changes in the 6-minute walk test: A pilot study | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.ijcard.2017.10.074 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://www.internationaljournalofcardiology.com/article/S0167-5273(17)34071-8/abstract | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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