Estimation of caffeine intake from analysis of caffeine metabolites in wastewater
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Otros documentos de la autoría: GRACIA LOR, EMMA; Rousis, Nikolaos I; Zuccato, Ettore; Bade, Richard; Baz Lomba, Jose Antonio; Castrignanò, Erika; Causanilles, Ana; Hernandez, Felix; Kasprzyk-Hordern, Barbara; Kinyua, Juliet; McCall, Ann-Kathrin; van Nuijs, Alexander; Plosz, Benedek; Ramin, Pedram; Ryu, Yeonsuk; Santos, Miguel M.; Thomas, Kevin V.; de Voogt, Pim; Yang, Zhugen; Castiglioni, Sara
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INVESTIGACIONMetadatos
Título
Estimation of caffeine intake from analysis of caffeine metabolites in wastewaterAutoría
Fecha de publicación
2017-12Editor
ElsevierCita bibliográfica
GRACIA-LOR, Emma, et al. Estimation of caffeine intake from analysis of caffeine metabolites in wastewater. Science of the Total Environment, 2017, vol. 609, p. 1582-1588.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0048969717319770#!Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten ... [+]
Caffeine metabolites in wastewater were investigated as potential biomarkers for assessing caffeine intake in a population. The main human urinary metabolites of caffeine were measured in the urban wastewater of ten European cities and the metabolic profiles in wastewater were compared with the human urinary excretion profile. A good match was found for 1,7-dimethyluric acid, an exclusive caffeine metabolite, suggesting that might be a suitable biomarker in wastewater for assessing population-level caffeine consumption. A correction factor was developed considering the percentage of excretion of this metabolite in humans, according to published pharmacokinetic studies. Daily caffeine intake estimated from wastewater analysis was compared with the average daily intake calculated from the average amount of coffee consumed by country per capita. Good agreement was found in some cities but further information is needed to standardize this approach. Wastewater analysis proved useful to providing additional local information on caffeine use. [-]
Proyecto de investigación
Financial support from the SEWPROF Marie Curie ITN project ‘A new paradigm in drug use and human health risk assessment: Sewage profiling at the community level’ [grant agreement 317205] supported by the European Union Seventh Framework Programme for research, technological development and demonstration and from the COST Action ES1307 “SCORE – Sewage biomarker analysis for community health assessment” is gratefully acknowledged. Emma Gracia-Lor extends her gratitude to Generalitat Valenciana, Conselleria d'Educació, Investigació, Cultura i Esport for her postdoctoral contract (APOSTD/2015, Programa VALi + d). Alexander van Nuijs acknowledges FWO Flanders (1285216N) for financial support. We are grateful to Christoph Ort for his comments and suggestions and to the personnel from all WWTPs for their support in wastewater sampling, particularly Francesco Poretti and Armando Foletti from Consorzio Depurazione Acque Lugano e Dintorni (CDALED) in Lugano for their kind support.Derechos de acceso
© 2017 Elsevier B.V. All rights reserved.
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info:eu-repo/semantics/openAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
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