Mostrar el registro sencillo del ítem
Effects of JTV-519 on stretch-induced manifestations of mechanoelectric feedback
dc.contributor.author | Del Canto, Irene | |
dc.contributor.author | Such-Miquel, Luis | |
dc.contributor.author | Brines, Laia | |
dc.contributor.author | Soler, Carlos | |
dc.contributor.author | Zarzoso, Manuel | |
dc.contributor.author | Calvo, Conrado | |
dc.contributor.author | Parra, Germán | |
dc.contributor.author | Tormos, Álvaro | |
dc.contributor.author | Alberola, Antonio | |
dc.contributor.author | Millet, José | |
dc.contributor.author | Such-Miquel, Luis | |
dc.contributor.author | Chorro, Francisco J. | |
dc.date.accessioned | 2017-07-10T07:59:45Z | |
dc.date.available | 2017-07-10T07:59:45Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | CANTO, Irene, et al. Effects of JTV‐519 on stretch‐induced manifestations of mechanoelectric feedback. Clinical and Experimental Pharmacology and Physiology, 2016, vol. 43, no 11, p. 1062-1070. | ca_CA |
dc.identifier.issn | 0305-1870 | |
dc.identifier.issn | 1440-1681 | |
dc.identifier.uri | http://hdl.handle.net/10234/168221 | |
dc.description.abstract | JTV-519 is a 1,4-benzothiazepine derivative with multichannel effects that inhibits Ca2+ release from the sarcoplasmic reticulum and stabilizes the closed state of the ryanodine receptor, preventing myocardial damage and the induction of arrhythmias during Ca2+ overload. Mechanical stretch increases cellular Na+ inflow, activates the reverse mode of the Na+/Ca2+ exchanger, and modifies Ca2+ handling and myocardial electrophysiology, favoring arrhythmogenesis. This study aims to determine whether JTV-519 modifies the stretch-induced manifestations of mechanoelectric feedback. The ventricular fibrillation (VF) modifications induced by acute stretch were studied in Langendorff-perfused rabbit hearts using epicardial multiple electrodes under control conditions (n=9) or during JTV-519 perfusion: 0.1 μmol/L (n=9) and 1 μmol/L (n=9). Spectral and mapping techniques were used to establish the baseline, stretch and post-stretch VF characteristics. JTV-519 slowed baseline VF and decreased activation complexity. These effects were dose-dependent (baseline VF dominant frequency: control=13.9±2.2 Hz; JTV 0.1 μmol/L=11.1±1.1 Hz, P<.01; JTV 1 μmol/L=6.6±1.1 Hz, P<.0001). The stretch-induced acceleration of VF (control=38.8%) was significantly reduced by JTV-519 0.1 μmol/L (19.8%) and abolished by JTV 1 μmol/L (−1.5%). During stretch, the VF activation complexity index was reduced in both JTV-519 series (control=1.60±0.15; JTV 0.1 μmol/L=1.13±0.3, P<.0001; JTV 1 μmol/L=0.57±0.21, P<.0001), and was independently related to VF dominant frequency (R=.82; P<.0001). The fifth percentile of the VF activation intervals, conduction velocity and wavelength entered the multiple linear regression model using dominant frequency as the dependent variable (R=−.84; P<.0001). In conclusion, JTV-519 slowed and simplified the baseline VF activation patterns and abolished the stretch-induced manifestations of mechanoelectric feedback. | ca_CA |
dc.description.sponsorShip | This work was supported by the Spanish Ministry of Economy and Competitiveness (Carlos III Health Institute)/European FEDER Grants FIS PI12/00407, PI15/01408, PIE15/00013 and RETIC “RIC” RD12/0042/0048, and by Generalitat Valenciana Grant PROMETEO FASEII 2014/037. | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Wiley | ca_CA |
dc.relation.isPartOf | Clinical and Experimental Pharmacology and Physiology, 2016, vol. 43, no 11 | ca_CA |
dc.rights | Copyright © John Wiley & Sons, Inc. All Rights Reserved | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | JTV-519 | ca_CA |
dc.subject | K201 | ca_CA |
dc.subject | mapping | ca_CA |
dc.subject | mechanoelectric feedback | ca_CA |
dc.subject | myocardial stretch | ca_CA |
dc.subject | ventricular fibrillation | ca_CA |
dc.title | Effects of JTV-519 on stretch-induced manifestations of mechanoelectric feedback | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1111/1440-1681.12630 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://onlinelibrary.wiley.com/doi/10.1111/1440-1681.12630/full | ca_CA |
Ficheros en el ítem
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
EDU_Articles [503]