The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation
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Otros documentos de la autoría: Sánchez-Sarasúa, Sandra; Moustafa, S.; García Avilés, Álvaro; López Climent, María Fernanda; Gomez-Cadenas, Aurelio; Olucha-Bordonau, Francisco E; Sánchez-Pérez, Ana María
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INVESTIGACIONMetadatos
Título
The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammationAutoría
Fecha de publicación
2016-10Editor
BioMed CentralCita bibliográfica
SÁNCHEZ-SARASÚA, Sandra, et al. The effect of abscisic acid chronic treatment on neuroinflammatory markers and memory in a rat model of high-fat diet induced neuroinflammation. Nutrition & Metabolism, 2016, vol. 13, no 1, p. 73.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-016-0137-3Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background
Western diet and lifestyle are associated with overweight, obesity, and type 2 diabetes, which, in turn, are correlated with neuroinflammation processes. Exercise and a healthy diet are important in the ... [+]
Background
Western diet and lifestyle are associated with overweight, obesity, and type 2 diabetes, which, in turn, are correlated with neuroinflammation processes. Exercise and a healthy diet are important in the prevention of these disorders. However, molecules inhibiting neuroinflammation might also be efficacious in the prevention and/or treatment of neurological disorders of inflammatory etiology. The abscisic acid (ABA) is a phytohormone involved in hydric-stress responses. This compound is not only found in plants but also in other organisms, including mammals. In rodents, ABA can play a beneficial role in the regulation of peripheral immune response and insulin action. Thus, we hypothesized that chronic ABA administration might exert a protective effect in a model of neuroinflammation induced by high-fat diet (HFD).
Methods
Male Wistar rats were fed with standard diet or HFD with or without ABA in the drinking water for 12 weeks. Glucose tolerance test and behavioral paradigms were performed to evaluate the peripheral and central effects of treatments. One-Way ANOVA was performed analyzed statistical differences between groups.
Results
The HFD induced insulin resistance peripherally and increased the levels of proinflammatory markers in in the brain. We observed that ABA restored glucose tolerance in HFD-fed rats, as expected. In addition, chronic ABA treatment rescued cognitive performance in these animals, while not affecting control diet fed animals. Moreover, it counteracted the changes induced by HFD in the hypothalamus; microglia activations and TNFα mRNA levels.
Conclusion
These results suggest that ABA might become a new therapeutic molecule improving the neuroinflammatory status and insulin resistance. [-]
Publicado en
Nutrition & Metabolism, 2016, vol. 13, no 1Derechos de acceso
© 2016 BioMed Central Ltd unless otherwise stated. Part of Springer Nature.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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