Preliminar study of calcium binding proteins in A β-Amyloid iinjected model
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Preliminar study of calcium binding proteins in A β-Amyloid iinjected modelAutoría
Tutor/Supervisor
Ros Bernal, FranciscoTutor/Supervisor; Universidad.Departamento
Universitat Jaume I. Unitat Predepartamental de MedicinaFecha de publicación
2016-09-22Editor
Universitat Jaume IResumen
Alzheimer's disease (AD) is the most common neurodegenerative disease and it is
characterized by a progressive cognitive decline with memory loss. Histopathological
examination of AD postmortem brains revealed the ... [+]
Alzheimer's disease (AD) is the most common neurodegenerative disease and it is
characterized by a progressive cognitive decline with memory loss. Histopathological
examination of AD postmortem brains revealed the presence of numerous senile
plaques (amyloid plaques) and neurofibrillary tangles (NFT).
The administration of Aβ25-35 into the hippocampus is predominantly used in animal
studies and has been shown to induce biochemical changes in animals which are
similar to what is observed in AD patients.
Recent human and preclinical studies have provided convincing evidence that AD is a
degenerative metabolic disease, which is mediated by impairments in brain insulin
responsiveness, glucose utilization, and energy metabolism.The insulin superfamily
comprises the vertebrate insulin, two insulin-like growth factors (IGF1, IGF2), four
insulin-like peptides (INSL3, INSL4, INSL5, INSL6), as well as three relaxin peptides
(RLN1, RLN2, RLN3). RLN3 accumulation and/or hyperinsulinemia may have similar
effects regarding deficient Aβ clearance. Previous data on the distribution of RLN3
fibres in the brain have shown a close correlation with areas that are specially sensitive
to AD pathologies including the medial septum, amygdala and hippocampus.
Numerous evidences suggest that a deregulation of Ca+2 signaling may play a major
role in disease progression. Different proteins, including CB, CR and PV, may offer
neuroprotection by maintaining calcium homeostasis. After having conducted the
study, we have noticed that the injection of Aβ 25-35 induce the same changes in
calcium-binding proteins expression in septum and hippocampus of the contralateral
hemisphere. [-]
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Treball Final de Màster Universitari en Investigació en Cervell i Conducta. Codi: SBM024. Curs: 2015/2016
Universitat Jaume I. Unitat Predepartamental de Medicina
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