The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion
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http://dx.doi.org/10.1007/s00213-014-3766-0 |
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Títol
The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropionAutoria
Data de publicació
2015Editor
Springer VerlagTipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://link.springer.com/article/10.1007/s00213-014-3766-0Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Rationale Depressed people show effort-related motivational
symptoms, such as anergia, retardation, lassitude, and fatigue.
Animal tests can model these motivational symptoms, and the
present studies characterized ... [+]
Rationale Depressed people show effort-related motivational
symptoms, such as anergia, retardation, lassitude, and fatigue.
Animal tests can model these motivational symptoms, and the
present studies characterized the effort-related effects of the
vesicular monoamine transport (VMAT-2) inhibitor
tetrabenazine. Tetrabenazine produces depressive symptoms
in humans and, at low doses, preferentially depletes
dopamine.
Objectives The current studies investigated the effects of
tetrabenazine on effort-based decision making using the Tmaze
barrier task.
Methods Rats were tested in a T-maze in which the choice
arms of the maze contain different reinforcement densities,
and under some conditions, a vertical barrier was placed in the
high-density arm to provide an effort-related challenge. The
first experiment assessed the effects of tetrabenazine under
different maze conditions: a barrier in the arm with 4 food
pellets and 2 pellets in the no barrier arm (4–2 barrier), 4
pellets in one arm and 2 pellets in the other with no barrier
in either arm (no barrier), and 4 pellets in the barrier arm with
no pellets in the other (4–0 barrier).
Results Tetrabenazine (0.25–0.75 mg/kg IP) decreased selection
of the high cost/high reward arm when the barrier was
present, but had no effect on choice under the no barrier and
4–0 barrier conditions. The effects of tetrabenazine on barrier
climbing in the 4–2 condition were reversed by the adenosine
A2A antagonist MSX-3 and the catecholamine uptake inhibitor
and antidepressant bupropion.
Conclusions These studies have implications for the development
of animal models of the motivational symptoms of
depression and other disorders. [-]
Publicat a
Psychopharmacology (2015) 232:1313–1323Drets d'accés
© Springer-Verlag Berlin Heidelberg 2014
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