Cocaine-induced plasticity in the cerebellum of sensitised mice
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Títol
Cocaine-induced plasticity in the cerebellum of sensitised miceAutoria
Data de publicació
2015Editor
Springer VerlagISSN
0033-3158; 1432-2072Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://link.springer.com/article/10.1007/s00213-015-4072-1Versió
info:eu-repo/semantics/submittedVersionParaules clau / Matèries
Resum
Rationale Prior research has accumulated a substantial
amount of evidence on the ability of cocaine to produce
short- and long-lasting molecular and structural plasticity in
the corticostriatal-limbic circuitry. ... [+]
Rationale Prior research has accumulated a substantial
amount of evidence on the ability of cocaine to produce
short- and long-lasting molecular and structural plasticity in
the corticostriatal-limbic circuitry. However, traditionally, the
cerebellum has not been included in the addiction circuitry,
even though growing evidence supports its involvement in the
behavioural changes observed after repeated drug
experiences.
Objectives In the present study, we explored the ability of
seven cocaine administrations to alter plasticity in the cerebellar
vermis.
Methods After six cocaine injections, one injection every
48 h, mice remained undisturbed for 1 month in their home
cages. Following this withdrawal period, they received a new
cocaine injection of a lower dose. Locomotion, behavioural
stereotypes and several molecular and structural cerebellar
parameters were evaluated.
Results Cerebellar proBDNF and mature BDNF levels were
both enhanced by cocaine. The high BDNF expression was
associated with dendritic sprouting and increased terminal size
in Purkinje neurons. Additionally, we found a reduction in
extracellular matrix components that might facilitate the subsequent
remodelling of Purkinje-nuclear neuron synapses.
Conclusions Although speculative, it is possible that these
cocaine-dependent cerebellar changes were incubated during
withdrawal and manifested by the last drug injection.
Importantly, the present findings indicate that cocaine is able
to promote plasticity modifications in the cerebellum of
sensitised animals similar to those in the basal ganglia. [-]
Publicat a
Psychopharmacology (2015) 232:4455–4467Drets d'accés
© Springer-Verlag Berlin Heidelberg 2015
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info:eu-repo/semantics/openAccess
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info:eu-repo/semantics/openAccess
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