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Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2
dc.contributor.author | Pascual, María | |
dc.contributor.author | Baliño, Pablo | |
dc.contributor.author | González Aragón, Carlos Manuel | |
dc.contributor.author | Guerri, Consuelo | |
dc.date.accessioned | 2016-06-07T11:56:13Z | |
dc.date.available | 2016-06-07T11:56:13Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | PASCUAL, María, et al. Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: role of TLR4 and TLR2. Neuropharmacology, 2015, vol. 89, p. 352-359. | ca_CA |
dc.identifier.issn | 0028-3908 | |
dc.identifier.issn | 1873-7064 | |
dc.identifier.uri | http://hdl.handle.net/10234/160407 | |
dc.description.abstract | Recent evidence supports the influence of neuroimmune system activation on behavior. We have demonstrated that ethanol activates the innate immune system by stimulating toll-like receptor 4 (TLR4) signaling in glial cells, which triggers the release of inflammatory mediators and causes neuroinflammation. The present study aimed to evaluate whether the ethanol-induced up-regulation of cytokines and chemokines is associated with anxiety-related behavior, 24 h after ethanol removal, and if TLR4 or TLR2 is involved in these effects. We used WT, TLR4-KO and TLR2-KO mice treated with alcohol for 5 months to show that chronic ethanol consumption increases the levels of cytokines (IL-1β, IL-17, TNF-α) and chemokines (MCP-1, MIP-1α, CX3CL1) in the striatum and serum (MCP-1, MIP-1α, CX3CL1) of WT mice. Alcohol deprivation for 24 h induces IFN-γ levels in the striatum and maintains high levels of some cytokines (IL-1β, IL-17) and chemokines (MIP-1α, CX3CL1) in this brain region. The latter events were associated with an increase in anxiogenic-related behavior, as evaluated by the dark and light box and the elevated plus maze tests. Notably, mice lacking TLR4 or TLR2 receptors are largely protected against ethanol-induced cytokine and chemokine release, and behavioral associated effects during alcohol abstinence. These data support the role of TLR4 and TLR2 responses in neuroinflammation and in anxiogenic-related behavior effects during ethanol deprivation, and also provide evidence that chemokines and cytokines can be biomarkers of ethanol-induced neuroimmune response. | ca_CA |
dc.description.sponsorShip | This work has been supported by grants from the Spanish Ministry of Economy and Competitiveness (SAF2012-33747), ERAB(EA-13-08); the Spanish Ministry of Health: the Institute Carlos III and FEDER Funds (RTA-Network RD12-0028-007), PNSD (2014-I010), GV-Consellería de Educación(ACOM 2014-062), PROMETEO II(2014-063). | ca_CA |
dc.format.extent | 8 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Springer | ca_CA |
dc.relation.isPartOf | Neuropharmacology, 2015, vol. 89 | ca_CA |
dc.rights | Copyright © Elsevier B.V. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | TLR4 | ca_CA |
dc.subject | ethanol | ca_CA |
dc.subject | anxiety | ca_CA |
dc.subject | withdrawal | ca_CA |
dc.subject | neuroinflammation | ca_CA |
dc.subject | cytokines | ca_CA |
dc.title | Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2 | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.neuropharm.2014.10.014 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S002839081400389X | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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