Listar INAM_Articles por autoría "9d74215b-02e2-46b1-bfbb-f6c7ec2b1170"
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Computational Study of the Inhibition of RgpB Gingipain, a Promising Target for the Treatment of Alzheimer’s Disease
Movilla Núñez, Santiago; Martí, Sergio; Roca, Maite; Moliner, Vicent American Chemical Society (2023-01-17)Alzheimer’s disease represents one of the most ambitious challenges for biomedical sciences due to the growing number of cases worldwide in the elderly population and the lack of efficient treatments. One of the recent ... -
Molecular Basis of RNA-Driven ATP Hydrolysis in DExH-Box Helicases
Movilla Núñez, Santiago; Roca, Maite; Moliner, Vicent; Magistrato, Alessandra American Chemical Society (2023-03-29)The spliceosome machinery catalyzes precursor messenger (pre-m)RNA splicing. In each cycle, the spliceosome experiences massive compositional and conformational remodeling fueled by the concerted action of specific ... -
Molecular Dynamics Simulations Elucidate the Molecular Basis of Pre-mRNA Translocation by the Prp2 Spliceosomal Helicase
Agrò, Sefora Naomi; Rozza, Riccardo; Movilla Núñez, Santiago; Aupič, Jana; Magistrato, Alessandra American Chemical Society (2023-06-28)The spliceosome machinery catalyzes precursor-messenger RNA (pre-mRNA) splicing by undergoing at each splicing cycle assembly, activation, catalysis, and disassembly processes, thanks to the concerted action of specific ... -
Unrevealing the Proteolytic Activity of RgpB Gingipain from Computational Simulations
Movilla Núñez, Santiago; Martí, Sergio; Roca, Maite; Moliner, Vicent American Chemical Society (2021-09-02)Alzheimer’s disease represents one of the greatest medical concerns for today’s population and health services. Its multifactorial inherent nature represents a challenge for its treatment and requires the development of a ...