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IRS1 expression in hippocampus is age-dependent and is required for mature spine maintenance and neuritogenesis
Sánchez-Sarasúa, Sandra; Meseguer Beltrán, Maria; García Díaz, Cristina; Beltrán-Bretones, Maria Teresa; ElMlili, Nisrin; Sánchez-Pérez, Ana María Elsevier (2022-01)Insulin and insulin-like growth factor type I (IGF-1) play prominent roles in brain activity throughout the lifespan. Insulin/IGF1 signaling starts with the activation of the intracellular insulin receptor substrates (IRS). ...