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Secondary Amine Catalysis in Enzyme Design: Broadening Protein Template Diversity through Genetic Code Expansion
Williams, Thomas L.; Taily, Irshad Maajid; Hatton, Lewis; Berezin, Andrey A; Wu, Yi-Lin; Moliner, Vicent; Świderek, Katarzyna; Tsai, Yu-Hsuan; Luk, Louis Y. P. Wiley (2024)Secondary amines, due to their reactivity, can transform protein templates into catalytically active entities, accelerating the development of artificial enzymes. However, existing methods, predominantly reliant on modified ...