Listar INAM_Articles por autoría "4fd3f249-72ae-483d-a3d7-02e03ba74baf"
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Glycoside Hydrolase Catalysis: Do Substrates and Mechanism-Based Covalent Inhibitors React via Matching Transition States?
Akintola, Oluwafemi; Farren-Dai, Marco; Ren, Weiwu; Bhosale, Sandeep; Britton, Robert; Świderek, Katarzyna; Moliner, Vicent; Bennet, Andrew J. American Chemical Society (2023-12-02)In this study, we look at how a catalytically efficient α-galactosidase stabilizes transition state (TS) charge delocalization for substrate hydrolysis. We then assess whether covalent inhibition of the enzyme by three ...