Listar INAM_Articles por autoría "45c1357f-d751-4f35-ab3f-cee267877f3e"
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Glycoside Hydrolase Catalysis: Do Substrates and Mechanism-Based Covalent Inhibitors React via Matching Transition States?
Akintola, Oluwafemi; Farren-Dai, Marco; Ren, Weiwu; Bhosale, Sandeep; Britton, Robert; Świderek, Katarzyna; Moliner, Vicent; Bennet, Andrew J. American Chemical Society (2023-12-02)In this study, we look at how a catalytically efficient α-galactosidase stabilizes transition state (TS) charge delocalization for substrate hydrolysis. We then assess whether covalent inhibition of the enzyme by three ...