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Impact of the Recognition Part of Dipeptidyl Nitroalkene Compounds on the Inhibition Mechanism of Cysteine Proteases Cruzain and Cathepsin L
(American Chemical Society, 2023-05-05)
Cysteine proteases (CPs) are an important class of enzymes, many of which are responsible for several human diseases. For instance, cruzain of protozoan parasite Trypanosoma cruzi is responsible for the Chagas disease, ...
Device Performance of Emerging Photovoltaic Materials (Version 2)
(Wiley, 2021-11-11)
Following the 1st release of the “Emerging photovoltaic (PV) reports”, the best achievements in the performance of emerging photovoltaic devices in diverse emerging photovoltaic research subjects are summarized, as reported ...
Electrochemical valorization of HMF using Ni/Graphite electrodes
(Elsevier, 2024-01)
The electrooxidation of 5-hydroxymethylfurfural (HMF) into 2,5- furandicarboxilic acid (FDCA) has been successfully accomplished using cost-effective NiO–OH electrodes, prepared through Ni electrodeposition on pencil ...
Glycoside Hydrolase Catalysis: Do Substrates and Mechanism-Based Covalent Inhibitors React via Matching Transition States?
(American Chemical Society, 2023-12-02)
In this study, we look at how a catalytically efficient α-galactosidase stabilizes transition state (TS) charge delocalization for substrate hydrolysis. We then assess whether covalent inhibition of the enzyme by three ...
ABA Supplementation Rescues IRS2 and BDNF mRNA Levels in a Triple-Transgenic Mice Model of Alzheimer’s Disease
(IOS Press, 2023-09-08)
Insulin resistance underlies Alzheimer’s disease (AD) by affecting neuroinflammation and brain-derived neurotrophic factor (BDNF) expression. Here, we evaluated the effect of early and late-start abscisic acid (ABA) ...
An Iron Bis(carbene) Catalyst for Low Overpotential CO2 Electroreduction to CO: Mechanistic Insights from Kinetic Zone Diagrams, Spectroscopy, and Theory
(American Chemical Society, 2021-12-08)
A common challenge in molecular electrocatalysis is the relationship between maximum activity and the overpotential required to reach that rate, with faster catalysts incurring higher overpotentials. This work follows a ...
Unprecedented solar water splitting of dendritic nanostructured Bi2O3 films by combined oxygen vacancy formation and Na2MoO4 doping
(ElsevierInternational Association for Hydrogen Energy, 2021-05-27)
We demonstrate the synergetic effect of Na2MoO4-doping and vacuum-annealing on dendritic nanostructured bismuth oxide (Bi2O3) thin films prepared by electrodeposition for visible-light-assisted photoelectrochemical (PEC) ...
High Shunt Resistance SnO2-PbO Electron Transport Layer for Perovskite Solar Cells Used in Low Lighting Applications
(Wiley, 2021)
Hybrid perovskites are promising materials for new sustainable photovoltaic applications to operate under low lighting conditions, such as the reuse of residual photons that are wasted during indoor lighting. The requirements ...
Impact of Warhead Modulations on the Covalent Inhibition of SARS-CoV2 Mpro Explored by QM\/MM Simulations
(American Chemical Society, 2021-12-26)
The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus-2, SARS-CoV-2, shows the need for effective antiviral treatments. Here, we present a simulation study of the inhibition of the SARS-CoV-2 ...
Gold nanoparticle-catalysed functionalization of carbon-hydrogen bonds by carbene transfer reactions
(The Royal Society of Chemistry, 2022-02-23)
Gold nanoparticles stabilized by NHC ligands and supported onto reduced graphene oxide (rGO) catalyse the functionalization of cyclohexane and benzene C–H bonds upon insertion of carbene CHCO2Et (from N2[double bond, length ...