ListarInstitute of Advanced Materials (INAM) por tema "protein engineering"

Mostrando ítems 1-2 de 2

    • openAccess   Engineering a Highly Regioselective Fungal Peroxygenase for the Synthesis of Hydroxy Fatty Acids 

      González-Benjumea, Alejandro; Gomez de Santos, Patricia; Fernández-García, Ángela; Aranda Oliden, María del Carmen; Wu, Yinqi; But, Andrada; Molina-Espeja, Patricia; Mate, Diana; Gonzalez-Perez, David; Zhang, Wuyuan; Kiebist, Jan; Scheibner, Katrin; Hofrichter, Martin; Świderek, Katarzyna; Moliner, Vicent; Sanz-Aparicio, Julia; Hollmann, Frank; Gutiérrez, Ana; Alcalde, Miguel John Wiley & Sons (2023-02-20)
      The hydroxylation of fatty acids is an appealing reaction in synthetic chemistry, although the lack of selective catalysts hampers its industrial implementation. In this study, we have engineered a highly regioselective ...

    • openAccess   Secondary Amine Catalysis in Enzyme Design: Broadening Protein Template Diversity through Genetic Code Expansion 

      Williams, Thomas L.; Taily, Irshad Maajid; Hatton, Lewis; Berezin, Andrey A; Wu, Yi-Lin; Moliner, Vicent; Świderek, Katarzyna; Tsai, Yu-Hsuan; Luk, Louis Y. P. Wiley (2024)
      Secondary amines, due to their reactivity, can transform protein templates into catalytically active entities, accelerating the development of artificial enzymes. However, existing methods, predominantly reliant on modified ...