Browsing Institute of Advanced Materials (INAM) by Keyword "molecules"
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Computational Study of the Inhibition of RgpB Gingipain, a Promising Target for the Treatment of Alzheimer’s Disease
American Chemical Society (2023-01-17)Alzheimer’s disease represents one of the most ambitious challenges for biomedical sciences due to the growing number of cases worldwide in the elderly population and the lack of efficient treatments. One of the recent ... -
“Lock and Key” and “Induced-Fit” Host–Guest Models in Two Digold(I)-Based Metallotweezers
American Chemical Society (2022-04-01)Two different metallotweezers, each with two pyrene–imidazolylidene–gold(I) arms, were used as hosts for a series of planar aromatic guests. The metallotweezer with a dibenzoacridinebis(alkynyl) spacer (1) orients the two ... -
Molecular Basis of RNA-Driven ATP Hydrolysis in DExH-Box Helicases
American Chemical Society (2023-03-29)The spliceosome machinery catalyzes precursor messenger (pre-m)RNA splicing. In each cycle, the spliceosome experiences massive compositional and conformational remodeling fueled by the concerted action of specific ...