Browsing Institute of Advanced Materials (INAM) by Author "60005c2c-b7ca-46fb-8d2f-294f4ab48f3c"
Now showing items 1-1 of 1
-
Glycoside Hydrolase Catalysis: Do Substrates and Mechanism-Based Covalent Inhibitors React via Matching Transition States?
Akintola, Oluwafemi; Farren-Dai, Marco; Ren, Weiwu; Bhosale, Sandeep; Britton, Robert; Świderek, Katarzyna; Moliner, Vicent; Bennet, Andrew J. American Chemical Society (2023-12-02)In this study, we look at how a catalytically efficient α-galactosidase stabilizes transition state (TS) charge delocalization for substrate hydrolysis. We then assess whether covalent inhibition of the enzyme by three ...