Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failure
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INVESTIGACIONMetadades
Títol
Prognostic value of the interaction between galectin-3 and antigen carbohydrate 125 in acute heart failureAutoria
Data de publicació
2015Editor
Public Library of ScienceISSN
1932-6203Cita bibliogràfica
Núñez J, Rabinovich GA, Sandino J, Mainar L, Palau P, Santas E, et al. (2015) Prognostic Value of the Interaction between Galectin-3 and Antigen Carbohydrate 125 in Acute Heart Failure. PLoS ONE 10(4): e0122360. doi:10.1371/journal.pone.0122360Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122360Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Aims
Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have emerged as robust prognostic biomarkers in heart failure. Experimental data have also suggested a potential molecular interaction between CA125 and ... [+]
Aims
Galectin-3 (Gal-3) and carbohydrate antigen 125 (CA125) have emerged as robust prognostic biomarkers in heart failure. Experimental data have also suggested a potential molecular interaction between CA125 and Gal-3; however, the biological and clinical relevance of this interaction is still uncertain. We sought to evaluate, in patients admitted for acute heart failure, the association between plasma Gal-3 with all-cause mortality and the risk for rehospitalizations among high and low levels of CA125.
Methods and Results
We included 264 consecutive patients admitted for acute heart failure to the Cardiology Department in a third-level center. Both biomarkers were measured on admission. Negative binomial and Cox regression models were used to evaluate the prognostic effect of the interaction between Gal-3 and CA125 (dichotomized by its median) with hospital readmission and all-cause mortality, respectively. During a median follow-up of 2 years (IQR = 1-2.8), 108 (40.9%) patients deaths and 365 rehospitalizations in 171 (69.5%) patients were registered. In a multivariable setting, the effect of Gal-3 on mortality and rehospitalization was differentially mediated by CA125 (p = 0.007 and p<0.001, respectively). Indeed, in patients with CA125 above median (>67 U/ml), values across the continuum of Gal-3 showed a positive and almost linear relationship with either the risk of death or rehospitalization. Conversely, when CA125 was below median (≤67 U/ml), Gal-3 lacked any prognostic effect on both endpoints.
Conclusion
In patients with acute heart failure, Gal-3 was strongly associated with higher risk of long-term mortality and repeated rehospitalizations, but only in those patients exhibiting higher values of CA125 (above 67 U/ml). [-]
Publicat a
PLOS ONE Volumen: 10 Número: 4 Número de artículo: e0122360Drets d'accés
info:eu-repo/semantics/openAccess
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Except where otherwise noted, this item's license is described as © 2015 Núñez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited