Biological characterization of a new silicon based coating developed for dental implants
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http://dx.doi.org/10.1007/s10856-016-5690-9 |
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Títol
Biological characterization of a new silicon based coating developed for dental implantsAutoria
Data de publicació
2016-04Editor
SpringerCita bibliogràfica
MARTÍNEZ-IBÁÑEZ, M., et al. Biological characterization of a new silicon based coating developed for dental implants. Journal of Materials Science: Materials in Medicine, 2016, vol. 27, no 4, p. 1-9.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
http://link.springer.com/article/10.1007/s10856-016-5690-9Paraules clau / Matèries
Resum
Taking into account the influence of Si in osteoblast cell proliferation, a series of sol–gel derived silicon based coating was prepared by controlling the process parameters and varying the different Si-alkoxide ... [+]
Taking into account the influence of Si in osteoblast cell proliferation, a series of sol–gel derived silicon based coating was prepared by controlling the process parameters and varying the different Si-alkoxide precursors molar rate in order to obtain materials able to release Si compounds. For this purpose, methyltrimethoxysilane (MTMOS) and tetraethyl orthosilicate (TEOS) were hydrolysed together and the sol obtained was used to dip-coat the different substrates. The silicon release ability of the coatings was tested finding that it was dependent on the TEOS precursor content, reaching a Si amount value around ninefolds higher for coatings with TEOS than for the pure MTMOS material. To test the effect of this released Si, the in vitro performance of developed coatings was tested with human adipose mesenchymal stem cells finding a significantly higher proliferation and mineralization on the coating with the higher TEOS content. For in vivo evaluation of the biocompatibility, coated implants were placed in the tibia of the rabbit and a histological analysis was performed. The evaluation of parameters such as the bone marrow state, the presence of giant cells and the fibrous capsule proved the biocompatibility of the developed coatings. Furthermore, coated implants seemed to produce a qualitatively higher osteoblastic activity and a higher number of bone spicules than the control (uncoated commercial SLA titanium dental implant). [-]
Publicat a
Journal of Materials Science: Materials in Medicine Volume 27, Issue 4, 1 April 2016, Article number 80Drets d'accés
© Springer International Publishing AG, Part of Springer Science+Business Media
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